Resources for Advanced Research Projects Agency for Health (ARPA-H) Applications

About ARPA-H

The newly launched Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs – ranging from molecular to societal – to provide transformative health solutions for all. A new component of the U.S. Department of Health and Human Services, ARPA-H is authorized with a budget of $1 billion for Fiscal Year 2023.

The agency works to advance high-potential, high-impact biomedical and health research that cannot be readily accomplished through traditional research or commercial activity.

This new agency released its first Broad Agency Announcement (request for proposals) on March 15, 2023. The proposal process differs from that typically utilized by the National Institutes of Health or other federal agencies and includes two phases: a 3-page abstract followed by a full proposal (if invited).

photo of the US capitol

Open Funding Opportunities*

HEROES Health Care Rewards to Achieve Improved Outcomes
THEA Transplantation of Human Eye Allografts
PARADIGM Platform Accelerating Rural Access to Distributed and Integrated Medical Care
  • Proposers’ Day (details forthcoming) registration closes on February 5, 2024 at 5PM ET. ARPA-H intends to host a PARADIGM Proposers’ Day in Phoenix, AZ during the week of February 12, 2024.  Additional details will be provided as it becomes available.
  • Abstract Due Date: February 27, 2024, 4PM ET
  • Full Proposal Due Date: April 26, 2024
Antigens Predicted for Broad Viral Efficacy through Computational Experimentation (APECx)
  • Full Proposal Due Date: 5:00 PM EST February 16, 2024
First Agency-wide Open BAA
  •  Closes March 14, 2024

*Please respond to this call for intent to submit if you are interested in or are currently applying for an ARPA-H funding opportunity

Support and Resources for U-M Researchers

Support Teams

The Office of the Vice President for Research is working to aggregate and develop new resources to support teams from across the University of Michigan in their pursuit of ARPA-H funding by:

    • Disseminating timely information on ARPA-H opportunities
    • Providing resources to support faculty in developing successful applications to ARPA-H
    • Identifying program manager candidates from within the U-M research community
    • Creating a network of faculty interested in ARPA-H funding

OVPR’s Office of Research Development can provide proposal management support, including timelines and task lists, drafting supporting documents, editing, and graphic design.

Coaching Programs

OVPR has recruited U-M faculty with strong track records of DARPA support and mentors-in-residence from Innovation Partnerships to serve as peer coaches for researchers seeking ARPA-H funding. There are two coaching options available, and U-M researchers able to apply for one or both:

ARPA-H Programs

RECENTLY ANNOUNCED

Funding opportunities provided by the Advanced Research Projects Agency for Health (ARPA-H) typically allow one application per institution, with the exception of Open Call BAA. Please respond to this call for intent to submit if you are interested in or are currently applying for an ARPA-H funding opportunity (outside of the Open Call BAA). To submit the call for intent, provide your contact information, title of your abstract or proposal, and the name of the ARPA-H solicitation you are applying to.

HEROES Health Care Rewards to Achieve Improved Outcomes

HEalth care Rewards to Achieve Improved OutcomES (HEROES) aims to trial and validate a radically different approach to creating preventative care incentives in the health market. This approach involves offering direct payments to individual “health catalysts” – such as non-profits or care consortiums – that successfully implement preventative care campaigns that improve the rates for specific health harms in an entire geographic population.

THEA Transplantation of Human Eye Allografts

The Transplantation of Human Eye Allografts, or THEA, program intends to enable whole functional eye transplantation to restore vision for the blind and visually impaired. In addition, THEA aims to develop new technologies or therapies to preserve or regrow nerves from the eye to the brain. These regenerative solutions could help prevent degenerative blindness and are a necessary step toward successful whole eye transplantation.  

PARADIGM Platform Accelerating Rural Access to Distributed and Integrated Medical Care

The Platform Accelerating Rural Access to Distributed and InteGrated Medical Care (PARADIGM) program aims to address the current challenges in rural health by creating a scalable vehicle platform that can provide advanced medical services outside of a hospital setting. Building on recent developments in fields ranging from satellite communication to medical device miniaturization, this mobile care platform will allow health providers to meet rural patients where they are.  

    • Proposers’ Day (details forthcoming) registration closes on February 5, 2024 at 5PM ET. ARPA-H intends to host a PARADIGM Proposers’ Day in Phoenix, AZ during the week of February 12, 2024.  Additional details will be provided as it becomes available.
    • Abstract Due Date: February 27, 2024, 4PM ET
    • Full Proposal Due Date: April 26, 2024

ONGOING

APECx 

The Antigens Predicted for Broad Viral Efficacy through Computational Experimentation (APECx) program aims to transform vaccine antigen discovery, first by developing toolkits that successfully design broadly effective antigens, targeting entire viral families, and then demonstrating the toolkits’ accuracy by evaluating candidate vaccine antigens in clinical trials.

If successful, the APECx toolkit and subsequent product development will demonstrate the possibility of broadly effective vaccines against multiple virus threats and eliminate entire types of viruses that are responsible for causing cancer, autoimmune disease, chronic illness, emerging infections, and potential pandemics.

Full Proposal Due Date: 5:00 PM EST February 16, 2024

Agency-wide Open BAA

ARPA-H opened its first Agency-wide Open Broad Agency Announcement (Open BAA), seeking funding proposals for research aiming to improve health outcomes across patient populations, communities, diseases, and health conditions. The BAA calls for proposals to outline breakthrough research and technological advancements.

Closes March 14, 2024

Stay Informed

If you are interested in learning more about ARPA-H, please sign up for the OVPR ARPA-H Listserv.

Questions

If you are seeking assistance on an application, please contact ovpr-arpa-h@umich.edu, or Lisa Prosser, lisapros@umich.edu.