Resources for Advanced Research Projects Agency for Health (ARPA-H) Applications

About ARPA-H

The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs – ranging from molecular to societal – to provide transformative health solutions for all. A component of the U.S. Department of Health and Human Services, ARPA-H is authorized with a budget of $1 billion for Fiscal Year 2023.

The agency works to advance high-potential, high-impact biomedical and health research that cannot be readily accomplished through traditional research or commercial activity.

This agency released its first Broad Agency Announcement (request for proposals) on March 15, 2023. The proposal process differs from that typically utilized by the National Institutes of Health or other federal agencies and includes two phases: a 3-page abstract followed by a full proposal (if invited).

photo of the US capitol

Open Funding Opportunities*

ARPA-H Joins DARPA on AI Cyber Challenge AIxCC
  • ARPA-H Joins DARPA on AI Cyber Challenge AIxCC
    • DARPA’s Artificial Intelligence Cyber Challenge (AIxCC) will bring together the foremost experts in AI and cybersecurity to safegaurd the software critical to all Americans.
    • AIxCC is a two-year competition that asks competitors to design novel AI tools and capabilities to find and fix vulnerabilities in software used in critical infrastructures.
(BREATHE) Building Resilient Environments for Air and Total Health
  • (BREATHE) Building Resilient Environments for Air and Total Health
    • Solution Summary due date: June 7, 2024
    • Proposal due date: August 12, 2024
    • U-M Opportunity Kick-off: Wednesday, May 8 at 12 pm EDT via Zoom. REGISTER.
(LIGHT) Lymphatic Imaging, Genomics, and Phenotyping Technologies
  • (LIGHT) Lymphatic Imaging, Genomics, and Phenotyping Technologies
(PRINT) Personalized Regenerative Immunocompetent Nanotechnology Tissue
  • (PRINT) Personalized Regenerative Immunocompetent Nanotechnology Tissue
    • Submission deadline forthcoming 
    • U-M Opportunity Kick-off: Friday, May 10 at 2 pm ET via Zoom. REGISTERthis event has been cancelled. Please reach out to Adrianna Trusiak with any questions.
(EMBODY) Engineering of Immune Cells Inside the Body
  • (EMBODY) Engineering of Immune Cells Inside the Body
    • Proposal due date: June 11, 2024, 5:00 PM EDT
ADAPT - ADvanced Analysis for Precision cancer Therapy
Mission Office-Specific Innovative Solutions Openings (ISOs)

*Please respond to this call for intent to submit if you are interested in or are currently applying for an ARPA-H funding opportunity

Resources and Support for U-M Researchers

Coaching Programs, Workshops & Informational Sessions

OVPR’s Office of Research Development can provide proposal management support, including timelines and task lists, drafting supporting documents, editing, and graphic design.

OVPR has also recruited U-M faculty with strong track records of DARPA support and mentors-in-residence from Innovation Partnerships to serve as peer coaches for researchers seeking ARPA-H funding. 

OVPR One-on-One Coaching

Please note that one-on-one OVPR support is available! Our team can work with faculty who are interested in developing a proposal for ARPA-H in a number of different ways – from consulting on how to frame your research using the Heilmeier questions to reviewing drafts or supporting proposal development. Applicants should plan to submit to ARPA-H within six months. Request 1:1 ARPA-H support here.

OVPR Informational Kickoff Sessions

(PRINT) Personalized Regenerative Immunocompetent Nanotechnology Tissue

  • U-M Opportunity Kick-off: Friday, May 10 at 2 pm ET via Zoom. REGISTERthis event has been cancelled. Please reach out to Adrianna Trusiak with any questions.

(LIGHT) Lymphatic Imaging, Genomics, and Phenotyping Technologies

  • U-M Opportunity Kick-off: Friday, May 17 at 12 pm EDT via Zoom. REGISTER
OVPR Workshops

Faculty who are interested in ARPA-H funding will have an opportunity to learn more about the ARPA-H proposal format. The workshop will cover what we know about ARPA-H, and give faculty tools to develop their research idea in the framework of the ARPA-(H)eilmeir Questions. We’ll also provide an orientation to the ongoing tools, templates and services OVPR is providing to faculty interested in pursuing ARPA-H funding.

Upcoming workshops:
  • Monday, May 20, 2024 11:00 a.m. – 12:30 p.m. REGISTER
Previous workshop recordings:

 

Support Teams

The Office of the Vice President for Research is working to aggregate and develop new resources to support teams from across the University of Michigan in their pursuit of ARPA-H funding by:

    • Disseminating timely information on ARPA-H opportunities
    • Providing resources to support faculty in developing successful applications to ARPA-H
    • Identifying program manager candidates from within the U-M research community
    • Creating a network of faculty interested in ARPA-H funding

Stay Informed

If you are interested in learning more about ARPA-H, please sign up for the OVPR ARPA-H Listserv.

Questions

If you are seeking assistance on an application, please contact ovpr-arpa-h@umich.edu, or Lisa Prosser, lisapros@umich.edu.

ARPA-H Programs

RECENTLY ANNOUNCED

Funding opportunities provided by the Advanced Research Projects Agency for Health (ARPA-H) typically allow one application per institution, with the exception of Open Call BAA. Please respond to this call for intent to submit if you are interested in or are currently applying for an ARPA-H funding opportunity (outside of the Open Call BAA). To submit the call for intent, provide your contact information, title of your abstract or proposal, and the name of the ARPA-H solicitation you are applying to.

(LIGHT) Lymphatic Imaging, Genomics, and Phenotyping Technologies

Lymphatic vessels are tiny and translucent, making them much harder to see than blood vessels. Lymph fluid moves through them at a slow rate and low pressure, preventing many of the diagnostic techniques used for veins and arteries from being effective. Lymph fluid itself is also highly variable in composition.  

(BREATHE) Building Resilient Environments for Air and Total Health

The Building Resilient Environments for Air and Total HEalth (BREATHE) program envisions smart building systems that monitor and respond to changes in indoor air quality. Green buildings balance thermal comfort and energy efficiency and BREATHE aims to employ similar approaches to handle indoor pathogen and allergen exposure.

  • Solution Summary due date: June 7, 2024
  • Proposal due date: August 12, 2024
  • U-M Opportunity Kick-off: Wednesday, May 8 at 12 pm EDT via Zoom. REGISTER
(EMBODY) Engineering of Immune Cells Inside the Body 

The Engineering of Immune Cells Inside the Body, or EMBODY, program aims to develop an adaptable, low-cost platform where cells in the body are given instructions to adjust their behavior. By moving the creation of specially trained immune cells out of the lab and in vivo, this platform could eliminate the time, cost, and access hurdles faced by traditional immune cell therapy manufacturing.

  • Proposal due date: June 11, 2024, 5:00 PM EDT
  • U-M Opportunity Kick-off: Friday, April 19 at 11 am EDT via Zoom. REGISTER.  
(PRINT) Personalized Regenerative Immunocompetent Nanotechnology Tissue 

The Personalized Regenerative Immunocompetent Nanotechnology Tissue (PRINT) program intends to use state-of-the-art bioprinting technology and a regenerative medicine approach to 3D print  personalized, on demand organs that do not require immunosuppressive drugs. The goal is to use patient cells or a biobank to quickly produce immune- and blood type-matched replacement organs, such as kidneys, hearts, and lungs.

  • Submission deadline forthcoming 
  • U-M Opportunity Kick-off: Friday, May 10 at 2 pm ET via Zoom. REGISTER
ARPA-H Joins DARPA on AI Cyber Challenge AIxCC

DARPA’s Artificial Intelligence Cyber Challenge (AIxCC) will bring together the foremost experts in AI and cybersecurity to safegaurd the software critical to all Americans.The Challenge seeks to find new solutions to address critical vulnerabilities in our nation’s hospitals, pharmacies, and medical devices. AIxCC is a two-year competition that asks competitors to design novel AI tools and capabilities to find and fix vulnerabilities in software used in critical infrastructures.

    ONGOING

    ADAPT – ADvanced Analysis for Precision cancer Therapy

    The ADvanced Analysis for Precision cancer Therapy (ADAPT) program aims to harness advanced technologies and a deep understanding of tumor biology to build cancer biomarkers. By tracking tumor changes before, during, and after treatment, clinicians can pinpoint alterations in tumor traits, enabling a more proactive response to cancer care. 

    Sprint for Women’s Health 

    The ARPA-H Sprint for Women’s Health’s new request for solutions (RFS) funding opportunity seeks unconventional approaches and innovative new avenues to push high-impact biomedical research forward to improve women’s health outcomes. The Sprint for Women’s Health will use two funding tracks to foster transformative research and development efforts. One for early-stage research, or “Spark” solutions and the other for later-stage development, or “LaunchPad” solutions.

    Mission Office-specific Innovative Solutions Openings (ISOs)

    To enhance our ability to support initiatives that align with our mission and Strategic Plan, the Advanced Research Projects Agency for Health (ARPA-H) is now accepting submissions to its Mission Office-specific ISOs. The four Mission Office-specific ISOs include:

    • Health Science Futures – Accelerating advances across research areas and removing limitations that stymie progress towards solutions for broad ranges of disease and conditions. View the Health Science Futures ISO on SAM.gov.
    • Proactive Health – Creating capabilities to detect and characterize disease risk and promote treatments and behaviors to anticipate threats whether viral, bacterial, chemical, physical, or psychological. View the Proactive Health ISO on SAM.gov.
    • Resilient Systems – Developing capabilities, business models, and integrations to endure crisis such as pandemics, social disruption, and economic instability. View the Resilient Systems ISO on SAM.gov.
    • Scalable Solutions – Addressing challenges including geography, distribution, manufacturing, data and information, and economies of scale to develop impactful, timely, and equitable solutions. View the Scalable Solutions ISO on SAM.gov.