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COVID-19 Research Index

Researchers across a wide variety of disciplines at the University of Michigan are using their expertise to address the global COVID-19 pandemic. The Office of the Vice President for Research created the following COVID-19 Research Index to increase awareness and foster collaboration among U-M researchers studying coronavirus. Please note the projects listed below are in various stages of development, from planning to fully launched.

Basic Laboratory Research Unrelated to Therapeutics

  1. Neutrophil extracellular traps in COVID-19 inflammatory storm

    • ​​​Principal Investigator: Jason Knight, Medical School

    • Project Summary: This project is in pursuit of the hypothesis that levels of circulating neutrophil extracellular traps (NETs) will predict COVID-19 patients at risk for severe disease, while potentially illuminating new and actionable neutrophil-specific therapeutic targets. March 31

  2. Identification of host factors required for SARS-CoV-2 infection and reagent generation

    • ​Principal Investigator: Andrew Tai, Medical School

    • Project Summary: We will be collaborating on a whole-genome CRISPR screen to identify host dependency factors for SARS-CoV-2 infection. In addition, we will be working to develop models of SARS-CoV-2 entry and replication that can be used at BSL-2 containment, which will help accelerate discovery of SARS-CoV-2 therapeutics. April 1

  3. Whole-genome CRISPR screen for cellular determinants of COVID-19 infection

    • ​Principal Investigator: David Ginsburg, Medical School

    • Project Summary: A team of U-M researchers is applying its expertise in genome-scale CRISPR screening to identify novel genetic interactions relevant to COVID-19 viral infection. They are screening for mutants with decreased cell surface abundance of the receptor (ACE2) used by the COVID-19 virus to enter cells, as well as mutants with decreased internalization of the COVID-19 virus glycoprotein that binds ACE2 to mediate viral entry. Researchers also are collaborating with U-M virology laboratories to develop a screen for mutants that are resistant to virus-mediated cytotoxicity. April 1

  4. Transgenic Rats for COVID-19 Vaccine Research

    • ​​Principal Investigator: Thomas Saunders, Medical School

    • Project Summary: Mirimus, Inc. is working with the University of Michigan Transgenic Core to produce transgenic rats that will express human ACE2 and CD147 coronavirus receptor proteins. The rats will be designed so that they do not express the orthologous rat proteins. An animal model that can only express human coronavirus receptor proteins is an ideal model for vaccine research. April 1

  5. ​Computer Modeling of Effects of COVID-19 Infection on Regional Pulmonary Blood Flow, Oxygen Exchange, and VQ Matching

    • Principal Investigator: Daniel Beard, Medical School

    • Project Summary: We have developed a multi-scale model of regional ventilation and alveolar blood flow regulation to study the mechanisms of ventilation-perfusion matching. Based on preliminary data on effects of Covid-19 infection and immune response we are working to adapt this model to simulate the relevant pathophysiological effects on oxygen transport. April 2

  6. SARS-CoV-2 infection of T cells

    • ​​Co-Principal Investigators: Philip D. King and Akira Ono, Medical School

    • Project Summary: Recent clinical data from Wuhan indicates a loss of T lymphocytes in Covid-19 patients that correlates with disease severity. Covid-19 research in the King and Ono labs is aimed at understanding if SARS-CoV-2, in addition to infecting epithelial cells, also infects T lymphocytes, which could explain T cell loss and could contribute to disease pathology. April 3

  7. Working Memory Training in Older Adults (HUM00108556), and Enhancing Working Memory Training with Concurrent Transcranial Direct Stimulation Study In Older Adults HUM00139673

    • ​​Principal Investigator: John Jonides, College of Literature, Science, and the Arts

    • Project Summary: The project aims to examine what people understand about exponential growth as it pertains to the virus and what the consequence for that growth are for the health care system. April 3

  8. HUMAN Monoclonal neutralizing antibodies against SARS-COV-2

    • Principal Investigator: M Cascalho, Medical School

    • Project Summary: Cloning of MoAb from SARS-Cov-2 specific Bcells isolated from blood of recovered patients. April 3

  9. ​​Priming of CD8+ T cell responses to SARS-CoV2

    • Principal Investigator: Malini Raghavan, Medical School/College of Literature, Science, and the Arts

    • Project Summary: CD8+ T cells are an important component of the immune response against viral infections. This project will develop procedures to identify and amplify CD8+ T cells specific to SARS-Cov2, the virus that causes COVID-19. April 2

  10. ​SARS-CoV-2 Sequencing

    • ​​Principal Investigator: Adam Lauring, Medical School/College of Lit, Science and Arts

    • Project Summary: We will perform whole genome sequencing of SARS-CoV-2 from residual clinical specimens and other specimens collected through observational cohorts. These data will inform the transmission and spread of the virus in healthcare settings and communities. April 7

  11. Metabolic alarmins may drive COVID19 immunopathology

    • ​​Principal Investigator: Charles Schuler, Medical School

    • Project Summary: COVID-19 morbidity and mortality primarily impacts metabolically compromised individuals. We seek to characterize the metabolic state of such individuals and correlate this to clinical outcomes. April 9

  12. ​N95decon

    • ​​Principal Investigator: Kevin Fu, College of Engineering

    • Project Summary: An interdisciplinary project including the University of Michigan to guide hospitals worldwide on the science of decontamination methods for N95 masks reused by healthcare workers during the crisis shortage of PPE. Our technical documents appear on n95decon.org. April 13

  13. Administrative NIA Supplement t-Mechanisms of dysregulated immunity with aging

    • Principal Investigator: Daniel R. Goldstein and Jane Deng, Medical School

    • Project Summary: Emerging evidence during the current pandemic indicates that older people exhibit increased morbidity to COVID-19. Our proposal will examine whether the mechanism behind the increased mortality to viral infection with aging is due to dysregulated inflammation in lung alveolar epithelial cells. We also will employ lung alveolar epithelial cell culture to test potential promising novel therapeutic agents to mitigate against COVID-19 infection in lung alveolar epithelial cells particularly with aging. April 13

  14. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

    • Matthew O'Meara, Medical School & Comp Med and Bioinformatics

    •  In a collaboration with the UCSF QBI Corona Research Group, we have identified 332 human proteins that physically interact with viral proteins through affinity purification mass spectrometry when expressed in HEK293T cells. We then identified 69 drugs, clinical candidates, and pre-clinical compounds that target these host factors (https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3) April 13

  15. Humanized Mice for COVID-19 Vaccine Research

    • Principal Investigator: Thom Saunders, Medical School

    • Project Summary: Mirimus, Inc. is working with the University of Michigan Transgenic Core to produce transgenic mice that will express human ACE2 and CD147 coronavirus receptor proteins. The mice will be designed so that they do not express the orthologous mouse proteins. An animal model that can only express human coronavirus receptor proteins is an ideal model for vaccine research. April 22

  16. Hypertensive Transgenic Rats for COVID-19 Research

    • Principal Investigator: Thom Saunders, Medical School

    • Project Summary: Dr. Bina Joe is working with the University of Michigan Transgenic Core to generate transgenic rats that express the human ACE2 coronavirus receptor protein in a strain of rats with spontaneous hypertension (Dahl S). The rats will express human ACE2 in place of the rat Ace2 protein. Hypertension is the most prevalent comorbidity of human COVID-19 patients. hACE2 hypertensive rats will be infected with the SARS-CoV-2 virus to better understand how they interact to cause severe disease. Dr. Joe's Dahl S rat colony at the University of Toledo are descended from the original hypertensive rats established by Dr. Dahl in the 1960s. April 22

  17. Developing animal models of lung Coronavirus Infection

    • Co-Principal Investigators: Beth Moore, Kathy Gallagher, Daniel Goldstein; Medical School - Moore, Gallagher, Goldstein

    • Project Summary: This project seeks to develop a murine model of severe coronavirus pulmonary disease using a natural mouse coronavirus similar to human SARS-CoV2. These models could be used to ask mechanistic questions about the virus pathogenesis and interaction with the immune system in a model system that is accessible to most investigators without requiring BSL3 facilities. We will also determine if common comorbidities (diabetes, aging, immunosuppression) impact outcomes of infection in mice. April 22

  18. Cardiac injury in pediatric patients with COVID-19

    • Principal Investigator: Mark W. Russell, Medical School 

    • Project Summary: The proposed project aims to gain insight into the extent of cardiac involvement in pediatric patients diagnosed with COVID-19 infection. The study will be directed by the Pediatric Heart Network, a multicenter research collaborative that studies congenital and acquired heart disease in pediatric patients. It will involve testing residual blood samples from pediatric patients for biomarkers of myocardial injury including Troponin T and NT-proBNP. The aim will be to determine if long-term cardiac monitoring is indicated in pediatric patients who have recovered from COVID-19. April 22

  19. Role of the Nasal Microbiome in Covid-19 Infection Susceptibility in Asthmatic and Non-Asthmatic Adults

    • Principal Investigator: Yvonne Huang, Medical School 

    • Project Summary: The biology of increased susceptibility to Covid-19 infection among younger adults remains unclear with obesity followed by asthma reported as the two most prevalent co-morbidities among hospitalized patients between the ages of 18-49 (CDC MMWR April). Based on existing data linking differences in the nasal microbiome to increased lung inflammation in asthmatic adults, this project will characterize the nasal microbiome from swabs of COVID19- positive vs. -negative patients, with and without asthma, to examine whether distinct nasal microbiome features are associated with greater likelihood of being infected by Covid-19. April 22 

  20. 4-13-20 SURVEY04 Crowding at the Ballot Box

    • Principal Investigator: Joshua Ackerman,   College of Lit, Science & Arts / Institute for Social Research

    • Project Summary: Prior research has shown that concerns about infectious disease lead people to view social situations as more crowded and confining. The current project considers implications of this for voting attitudes and behavior by testing whether COVID-19 concerns shape voter considerations of in-person vs. distance voting options. April 22

  21. Biology and Biomarkers for Stress Resilience: Animal Models and Human Studies

    • Principal Investigator: Dr. Huda Akil, Medical School

    • Project Summary: This project focuses on ascertaining the impact of COVID-19 social isolation and dislocation on U. of Michigan College Freshmen, including their stress hormone levels, changes in telomere length, circadian and activity patterns, emotional and mental health conditions including formal measures of depression and anxiety disorders. This a cohort of Freshmen who were already being studied, genotyped and ascertained on multiple variables, and this will allow us to understand biological and psychological factors of vulnerability and resilience. April 27 

  22. Impact of Clonal Hematopoiesis on COVID-19 morbidity and mortality

    • Principal Investigator: Terrence Wong, Jacob Kitzman, Medical School

    • Project Summary: Clonally expanded mutant hematopoietic populations may exhibit a hyperinflammatory response to stimuli. The goal of this project is determine if patients with clonal hematopoiesis are at increased risk of a hyperinflammatory response to COVID-19 with its associated morbidity and mortality. May 5

  23. Immune phenotyping of COVID19 patients by Mass Cytometry

    • Principal Investigator: Daniel R. Goldstein, Medica School

    • Project Summary: Our goal is to immune phenotype PBMCs from mild and severe case of COVID-19 patients to identify novel immune signatures that enrich with disease severity. May 5

  24. Modulation of macrophage immune responses by serum from COVID-19 patients

    • Principal Investigator: Katherine Gallagher, Medical School

    • Project Summary: Coagulation and thrombosis cause significant morbidity and mortality in COVID-19 patients. We will analyze COVID-19 patient serum to determine factors involved in initiation and resolution of these vascular complications. May 5

  25. Tractable murine models of COVID-19

    • Co-Principal Investigators: Thom Saunders and Phil King, Medical School

    • Project Summary: A conditional humanized mouse model of Covid-19 infection will be developed in which expression of the SARS-CoV-2 receptor can be disrupted in a cell type and tissue specific fashion. This model will invaluable to an understanding of mechanisms of Covid-19 pathogenesis and possible means of intervention. May 11

  26. Tissue examination of cardiovascular complications related to COVID

    • Principal Investigator: Yogen Kanthi, Medical School

    • Project Summary: This project aims to characterize the cardiovascular histopathologic findings in autopsy tissue from patients with COVID-19. May 13

  27. Impact of COVID-19 on Low Income Residents in Ypsilanti, Michigan

    • Principal Investigator: Patrick Meehan, School of Social Work

    • Project Summary: Needs assessment of low-income Ypsilanti residents on impact of COVID-19. Results will be shared with Washtenaw County policymakers to ensure equitable response to the pandemic locally. May 13

  28. Coagulofibrinolytic balance and endothelial protein C activation as key determinants of clinical outcome in a racially diverse cohort of COVID-19 patients

    • Principal Investigator: Colin Greineder, Medical School

    • Project Summary: Abnormal coagulation and fibrinolysis are now well-documented features of severe COVID-19 infection, although their etiology, interrelationship, and clinical significance remain incompletely understood. The overall goal of the current proposal is to determine the balance of coagulation and fibrinolysis in admitted patients from two institutions and to define its association with adverse clinical outcomes and abnormalities in the endothelial protein C pathway, which provides a crucial link between these proteolytic cascades. May 29

  29. Investigating PAI-1 and tPA as biomarkers in COVID-19 plasma

    • Principal Investigator: Daniel Lawrence, Medica School

    • Project Summary: Working with Drs. Jason Knight and Yogendra Kanthi, we are proposing to obtain plasma samples from COVID-19 patients with varying degrees of disease severity and from healthy controls, to look for an imbalance in the fibrinolytic system that might contribute to the unusual microvascular thrombosis observed in these patients. May 29

  30. Inflammatory myeloid/macrophage cell burden exacerbates the response and impacts recovery to the novel coronavirus

    • Principal Investigator: Megan Weivoda, School of Dentistry

    • Project Summary: We are evaluating how the inflammatory myeloid cell burden associated with aging, obesity, and diabetes may predispose patients to hyperinflammatory responses to COVID-19 infection. Secondly, we are testing whether COVID-19 proteins themselves drive inflammatory polarization that could predispose convalescent patients to secondary hyperinflammatory syndromes or autoimmune disease. May 29

  31. Develop NET-targeted inhibitors of neutrophil elastase for treatment of ARDS

    • Principal Investigator: Daniel Lawrence, Medical School

    • Project Summary: Neutrophil extracellular traps (NETs), containing the degradative protease neutrophil elastase, are a common feature of acute respiratory distress syndrome (ARDS). In COVID-19 ARDS is associated with high mortality and post-mortem studies report diffuse pulmonary alveolar damage. Working with Drs. Thomas Sisson, and Bethany Moore, we are proposing to use a mouse model of H1N1 (swine flu) influenza to examine the efficacy of a novel elastase inhibitor, MDI-1004 developed at the University of Michigan, for the treatment of viral pneumonia induced ARDS. May 29

Clinical Trials

  1. MSC to Treat COVID-related ARDS

    • ​​Principal Investigator: Francis Pagani, Medical School

    • Project Summary: The study is a clinical trial to evaluate a therapeutic modality. March 31

  2. The Randomized Elimination or ProLongation of Angiotensin Converting Enzyme inhibitors and angiotensin receptor blockers in Coronavirus Disease 2019 (REPLACE COVID trial)

    • ​​Principal Investigator: J. Brian Byrd, Medical School

    • Project Summary: REPLACE COVID is a randomized controlled clinical trial designed to address the pivotal clinical question should ACE inhibitors and angiotensin receptor blockers be continued in patients admitted to the hospital with COVID or strongly suspected COVID. I am currently setting up the University of Michigan site for this trial, which has already begun to enroll at the University of Pennsylvania. Our discussion of the current state-of-the-art on this topic has been viewed more than 200,000 times. It has also been featured by the American Society of Nephrology. Please refer to our paper discussing ACE inhibitor and ARB use in COVID. April 2

  3. A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734 ) in Participants with Moderate or Severe COVID-19

    • Principal Investigator: Daniel Kaul, Medical School

    • Project Summary: Michigan Medicine will begin enrolling on April 3 on two protocols sponsored by Gilead, one for moderate and one for severe COVID. Both of these trials are led by Dr. Daniel Kaul and are very similar in design involving the use of remdesivir, considered by many to be a promising antiviral therapy for COVID-19. April 3

  4. ​An Adaptive Phase 2/3, Randomized, Double-Blind, Placebo-Ccontrolled Study Assessing Efficacy and Safety of Sarilumab for Hospitalized Patients with COVID-19

    • ​​Principal Investigator: Kevin Gregg, Medical School

    • Project Summary: IL-6 inhibitor for COVID. April 3

  5. ​Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease

    • ​​Principal Investigator: Robert Hyzy, MD, Medical School

    • Project Summary: Hydroxychloroquine in the treatment of COVID. April 3

  6. ​CLINICAL TRIAL Pulmonary surfactant therapy for ARDS in COVID-19

    1. ​Principal Investigator: Krishnan Raghavendran; Medical School

    2. Project Summary: Currently no reliable therapy exists for COVID-19 patients with severe acute respiratory distress syndrome (ARDS) beyond the use of supportive critical care. Mortality rates in COVID-19 patients with ARDS are currently 30-50%, and added effective therapies are crucial. COVID-19 lung injury includes presumptive direct effects on type 2 alveolar epithelial cells (AEC2), which are stem cells for the alveoli and produce lung surfactant (LS). Inhibition of LS is a known contributor to ARDS, and AEC2 injury also leads to LS deficiency. Surfactant replacement therapy (SRT) is now standard for preterm infants in neonatal intensive care, and is also used successfully in many older infants and children. It is FDA approved with no known adverse off-target effects. In adults with ARDS, SRT has not been shown to improve survival in several prior studies that combined patients with different causes of lung injury including systemic disease in some cases. The difficulty of delivering surfactant to the alveoli in injured adult lungs also likely contributed. In this study SRT dosing strategies are designed to increase alveolar delivery efficiency based on recent computer modelling studies. Additionally, the use of SRT in patients whose ARDS stems from a single entity (COVID-19) improves the likelihood of success. April 13

  7. ​COVID-19 Infections: Healthcare Worker Exposure Response and Outcomes (HERO) Registry and Hydroxychloroquine (HERO-HCQ) Trial Program

    • Principal Investigator: Peter Higgins, Marisa Miceli, Medical School

    • Project Summary: Prophylaxis study of HCQ v Placebo in health care workers at risk of COVID19. The University of Michigan was selected to participate in the Healthcare Worker Exposure Response & Outcomes (HERO) registry and the first study using it. The HERO-HCQ trial focuses on how effective Hydroxychloroquine (HCQ) may be in protecting healthcare providers who are on the front lines of the pandemic. The clinical trial will study approximately 15,000 registry participants who will be randomized to receive either one month of HCQ or placebo, with the rates of infection monitored. After enrolling, healthcare workers can participate as much or as little as they like through weekly surveys and opportunities to participate in clinical trials.April 13

  8. ​CLINICAL TRIAL A Randomized Phase II Open Label Study of Alpha 1 – Antitrypsin (AAT) for Treatment of Hospitalized Patients with COVID-19

    • Principal Investigator: John Magenau, Medical School

    • Project Summary: It is hypothesized that COVID-19 pulmonary disease is associated with dysregulation of the immune response to viral infection. This proposal will address if immune-modulation with the FDA approved serine protease inhibitor alpha-1-antitrypsin (AAT) together with institutional treatment(s) can reduce the rate of progression to ICU admission. April 13

  9. OUTPATIENT Convalescent plasma adminstration in COVID-CLINCAL COORDINATING CENTER (working title)

    • Principal Investigator: William Barsan, Medical School

    • To serve as the CLINCAL COORDINATING CENTER for a trial to understand if administration prevents the need for inpatient hospitalization. Approached by NHLBI regarding outpatient trial. There is no protocol at this time, very nascent concept. UM resources are not being considered for this trial. We will update the index if Michigan Medicine is considered for as a performance site. April 17

  10. ​CLINICAL TRIAL Phase 3 randomised, double-blind, placebo-controlled, multi-center study to assess the efficacy and safety of ruxolitinib in patients with COVID-19 associated cytokine storm (RUXCOVID)

    • Principal Investigator: MeiLan Han, Medical School

    • Project Summary: Phase 3 randomised, double-blind, placebo-controlled, multi-center study to assess the efficacy and safety of ruxolitinib in patients with COVID-19 associated cytokine storm (RUXCOVID) April 22

  11. PETAL Network

    • Principal Investigator: Pauline Park, Medical School

    • Project Summary: This is an NHLBI-funded mulitcenter randomized trial comparing the effect of hydroxychloroquine versus placebo on clinical outcomes, measured using the COVID Ordinal Outcomes Scale at Day 15, among adults with COVID-19 requiring hospitalization. April 22

  12. Effectiveness of Perfluorocarbon Liquid Ventilation in Adult COVID patients on ECMO

    • Principal Investigator: Ronald B. Hirschl, M.D., Medical School

    • Project Summary: We wish to evaluate the effectiveness of partial liquid ventilation with perfluorocarbon in enhancing pulmonary function and gas exchange in patients with COVID-19 and respiratory failure. April 27

  13. CLINICAL TRIAL Propofol-Associated Hypertriglyceridemia in COVID-19 versus Non-COVID-19 Critically Ill Patients

    • ​​Principal Investigator: Michael Kenes, College of Pharmacy

    • Project Summary: This study seeks to characterize the incidence of and risk factors for development of propofol-associated hypertriglyceridemia in patients requiring sedation for management of COVID-19 ARDS compared to non-COVID-19 ARDS. April 7

  14. Delirium in Critically Ill Patients with COVID-19

    • Principal Investigator: Robert Hyzy, Medical School 

    • Project Summary: (1) To determine the epidemiology (i.e., prevalence) of cognitive impairment (i.e., acquired dementia) at 6 months and if hydroxychloroquine administration is associated with improvement in these same outcomes; (2) To determine the epidemiology of PTSD and depression at 6-months, and if hydroxychloroquine administration is associated with improvement in these same outcomes, and (3) To identify modifiable risk factors (e.g.,sedatives, isolation, intravenous fluids, pressor, ACE-inhibitor or ARB use, etc.) associated with worse long-term cognitive impairment, PTSD, and depression at 6 months. May 5

  15. Mood-Lifters for COVID-19

    • Principal Investigator: Patricia Deldin, Medical School College of Lit, Science & Arts

    • Project Summary: A brief 1 hour intervention is being tested for efficacy to help with Covid-19 anxiety. May 11

  16. Targeting TMPRSS2 expression as a therapy for coronavirus infection and replication

    • Principal Investigator: Ulka Vaishampayan, Medical School

    • Project Summary: A clinical trial to evaluate if TMPRSS2 inhibition will have a clinical impact in attenuating the course of COVID-19 infection.  May 13

  17. Pediatric Chest X-ray Findings during the COVID-19 Pandemic

    • Principal Investigator: Nicole Klekowski, Univ Hospitals & Health Center

    • Project Summary: This is a multi-center study housed at CHOP that is investigating changes in chest radiograph findings in pediatric patients presenting to the emergency department during the COVID-19 pandemic. May 29 

Diagnostics, Vaccines, Therapeutics and Drug Development

 

  1. Produce SARS-CoV-2 antigen for ELISA

    • Principal Investigator: Janet Smith​, Medical School/College of Literature, Science, and the Arts

    • Project Summary: The U-M Center for Structural Biology will produce and purify recombinant SARS-CoV-2 spike protein and the receptor binding domain of the spike protein. The proteins will be used in an ELISA assay being developed and validated by Aubree Gordon (SPH) and Donald Giacherio (Pathology). March 31

  2. ​Host response to vaccine adjuvants for emerging pathogens

    • ​​Principal Investigator: Yu Leo Lei, School of Dentistry/Medical School

    • Project Summary: The proposed research focuses on the host response to vaccine adjuvants and aims to design more effective adjuvant combinations to bypass intrinsic genetic restrictions. March 31

  3. Rapid and quantitative detection of multi-CoV-markers in fingertip blood

    • ​​Principal Investigator: Xudong (Sherman) Fan, College of Engineering

    • Project Summary: In collaboration with Optofluidic Bioassay, LLC, a U-M startup company, we are developing a portable device to rapidly and quantitatively analyze COVID-19 related antibodies and virus-related antigen using a droplet of blood. April 1

  4. Prophylactic vaccination against COVID-19

    • Principal Investigator: James Moon, College of Pharmacy

    • Project Summary: The Moon laboratory is developing new vaccines and anti-virals against SARS-CoV-2 and will test them in preclinical models. April 1

  5. Monitor mutations in and develop drugs to target nsp13, an essential RNA helicase in coronavirus

    • ​​Principal Investigator: Vivian G. Cheung, Medical School

    • Project Summary: Nsp13 is an RNA helicase that unwinds the RNA of coronavirus to allows its replication and transcription. We are a group of RNA biologists and physicians that aims to develop a universal anti-coronavirus treatment that targets nsp13. April 2

  6. An ImmunoBioEngineering Platform for Rapid and Scalable Biomanufacturing of Viral Vaccines

    • ​​Principal Investigator: Fei Wen, College of Engineering

    • Project Summary: To address the critical need for a coronavirus vaccine, a team of U-M researchers is working to develop a safe and rapid manufacturing system to produce COVID-19 virus-like particles as a vaccine. These particles mimic the morphology and protein composition of the actual coronavirus, but lack the viral genetic material, thus making them an ideal vaccine candidate. April 2

  7. STEMI Mimics in COVID-19

    • ​​Principal Investigator: J. Brian Byrd, Medical School

    • Project Summary: Dr. Byrd is leading an international group to report cases of conditions mimicking a cardiac emergency called ST elevation myocardial infarction among some patients with COVID-19. April 2

  8. ​Drug Reposition for COVID Lung Injury Treatment

    • ​​Principal Investigator: Lana Garmire, Medical School

    • Project Summary: Lung injury with severe respiratory failure is the leading cause of death in COVID-19. Inhibition of ACE2 caused by spike protein of (SARS)-CoV-2 is the most plausible mechanism of lung injury in COVID-19. We proposed to develop a computational strategy for drug reposition that could be promising of treating lung injuries in COVID-19. April 2

  9. ​Antibody fractionation and cytotoxicity testing of patient's COVID-19 convalescent plasma

    • ​​Principal Investigator: Sofia D. Merajver, Medical School/School of Public Health

    • Project Summary: We aim to understand what antibodies have been raised by persons who recovered from COVID-19, thus eventually developing a screening test to select the best donors of convalescent plasma for therapeutic purposes. April 2

  10. ​Molecular pathways of COVID-19 Acute Kidney Injury (AKI)

    • ​​Principal Investigator: Matthias Kretzler, Medical School

    • Project Summary: Molecular pathways of COVID19 kidney damage are defined using 800 kidney biopsy gene expression data sets (bulk and single cell RNAseq) from 5 international consortia covering diabetes, hypertension, autoimmune disease and organ transplantation. Mapping studies define expression and regulation of COVID19 receptors in kidney tissue in existing data and will map transcriptional responses of renal epithelial cells to virus infection in urinary single cell studies. April 3

  11. Neuropsychiatric Outcomes of COVID-19

    • ​Principal Investigator: Joanna Spencer-Sega, Medical School

    • Project Summary: This project will assess the rate and risk factors for of neuropsychiatric morbidity in survivors of COVID-19, and investigate biomarkers for neuropsychiatric risk. April 3

  12. Cardiopulmonary risk factors for COVID-19 illness in adults: SPIROMICS and MESA

    • ​​Principal Investigator: MeiLan Han, Medical School

    • Project Summary: SPIROMICS is a multi-center NHLBI observational study to longitudinally characterize COPD. We plan to implement a COVID questionnaire to understand risk factors for COVID infection and correlate infections with longterm outcomes among the COPD patient population. March 31

  13. Outcomes for COVID-19 Patients Requiring EEG Monitoring

    • ​​Principal Investigator: Chloe Hill, Medical School

    • Project Summary: We have proposed a descriptive study to characterize EEG findings in COVID-19 patients to better understand the neurological implications of this disease. April 3

  14. Resolving the distress and grief brought on by the COVID-19 crisis with step-care treatment

    • ​​Principal Investigator: David Fresco, Medical School/Institute for Social Research

    • Project Summary: Building on our past clinical trials work (i.e., Emotion Regulation Therapy [ERT]) 19-23 and grief (i.e., Complicated Grief Therapy [CGT]) 24-26, the overarching goals of this proposal are to assemble, refine and deploy a harmonized ERT/CGT intervention presented in an asynchronous mHealth format + minimal tele-therapy facilitation that can be intensified into therapist-directed individual teletherapy, as needed, to help resolve complicated forms of distress brought about by the COVID-19 virus and the resultant mandatory sequestration. April 6

  15. Integrative Ontological and Bioinformatics Studies on Coronavirus Diseases

    • Principal Investigator: Yongqun “Oliver” He, Medical School

    • Project Summary: We have initiated the development of a community-based Coronavirus Infectious Disease Ontology (CIDO), and aim to further develop and utilize CIDO for systematic modeling and analysis of coronavirus-related data and knowledge (such as etiology, hosts, host-coronavirus interactions), leading to rational design and development of effective and safe drugs and vaccines for COVID-19. April 9

  16. Validating a rapid point-of-care COVID-19 antibody test and assessing its utility in healthcare workers about to be deployed to inpatient COVID-19 duty

    • ​​Principal Investigators: James Baldwin and Charles Schuler, Medical School

    • Project Summary: We seek to validate a rapid, point-of-care COVID-19 antibody test, correlate the results with quantitative serology, and evaluate whether antibody testing predicts true immunity to COVID-19. We will offer this testing to healthcare workers being deployed to COVID-19 inpatient care. April 9

  17. ​Repurposing didanosine as a potential treatment for COVID-19 using scRNA-seq data

    • Principal Investigator: Fadhl Alakwaa, Medical School

    • Project Summary: Till today (10 April 2020), over 100 thousand people around the world have died from the COVID-19 pandemic. There is no approved drug or vaccine for COVID-19, although more than 10 clinical trials have been launched to test potential drugs. In an urgent response to this pandemic, I developed a bioinformatics pipeline to identify compounds and drugs candidates to potentially treat COVID-19. This pipeline is based on publicly available single-cell RNA-seq (scRNA-seq) data and the drug perturbation database “Library of Integrated Network-Based Cellular Signatures” (LINCS). I developed a ranking score system that prioritizes these drugs or small molecules. The four drugs with the highest total score (St) are: Didanosine, benzyl-quinazolin-4-yl-amine, camptothecin, and RO-90-7501. In conclusion, I have demonstrated the utility of bioinformatics for identifying drugs than can be repurposed for potentially treating COVID-19 patients. April 13

  18. ​Rapid and In-situ Breath Analysis for COVID-19 Diseases

    • Principal Investigator: Xudong (ShermanFan) & Kevin Ward, Medical School

    • Project Summary:  In the past 3 years, we have been working with the Department of Emergency Medicine and the University of Michigan Hospital ICU to use breath analysis to diagnose ARDS and monitor its trajectory over time. We have found that (1) there exist breathomic biomarkers related to ARDS; and (2) breath analysis is able to predict the ARDS onset and its trajectory >24 hours earlier than existing clinical method. In the project, we plan to construct portable breath analyzers and attach them to ventilation machines to monitor ARDS patients’ breath. April 13

  19. Real-Tme Registry for COVID Patients

    • Co-Principal Investigators: Swo for Gillies, Ansari, R Dickson, Medical School

    • Project Summary: This combined registry will provide high resolution data in real time to help physicians manage and predict the needs and outcomes of their specific patients. This data will provide much greater granularity and can be used as a predictive tool for information that is rapidly evolving. cgillies@med.umich.edu sardara@med.umich.edu rodickso@med.umich.edu April 13

  20. Breath Analysis for COVID-19 Diseases

    • Co-Principal Investigators: Swo for Kevin Ward, Xudong Fan

    • Project Summary: In the past 3 years, we have been working with the Department of Emergency Medicine and the University of Michigan Hospital ICU to use breath analysis to diagnose ARDS and monitor its trajectory over time. We have found that (1) there exist breathomic biomarkers related to ARDS; and (2) breath analysis is able to predict the ARDS onset and its trajectory >24 hours earlier than existing clinical method. In the project, we plan to construct portable breath analyzers and attach them to ventilation machines to monitor ARDS patients’ breath. keward@umich.edu xsfan@umich.edu April 13

  21. Screening of prioritized natural products library against Covid-19

    • Co-Principal Investigators: David H. Sherman; Ashootosh Tripathi, Life Sciences Institute; Medicinal Chemistry

    • Project Summary: UM Natural Products Discovery Core and David Sherman's laboratory at LSI is working with UM Center of Drug Repurposing for the screening of our specialized data-intensive natural products library against SARS-CoV2 in a bronchial airway viral infectivity assay. The short term goal is to identify high priority characterized natural products as an interventional therapeutics against COVID-19. In the long term, we intend to discover novel metabolites as not only interventional therapeutics but also discover lead candidates to develop agents for a post-exposure prophylactic response of the virus. April 14

  22. Discovery and Development of anti-SARS-CoV-2 Drug Leads from Natural Product Resources

    • Co-Principal Investigators: David H. Sherman, College of Pharmacy, Medical School, College of Lit, Science & Arts, Life Sciences Institute; Ashootosh Tripathi, Life Sciences Institute, College of Pharmacy; Jonny Sexton, College of Pharmacy, Medical School.

    • Project Summary:  We will employ a unique chemically diverse resource to identify novel natural product-based drug leads that can effectively inhibit the SARS CoV-2 virus in high content screening format and prevent the evolution of resistance mechanisms.  April 15

  23. SARS CoV2 infection of human intestinal enteroids

    • Principal Investigator: Christiane Wobus, Medical School 

    • Project Summary: The objective of this project is to develop non-transformed human intestinal enteroids into a physiologically relevant system for antiviral testing of drugs with SARS CoV2 efficacy in transformed cell lines. April 15

  24. Synthetic Gene Therapy for Enduring Immunoprotection from SARS CoV-2

    • Principal Investigator: Jeorg Lahann, College of Engineering

    • Project Summary: Vectored immunoprophylaxis has been advanced as an experimental therapeutic approach for a number of severe viral infections. Here, synthetic protein nanoparticles (sPNP) will be designed to deliver vectored antibody transgenes encoding broadly neutralizing antibodies against SARS CoV-2. April 22

  25. Defining Warfarin Dosage changes in COVID-19 Patients

    • Principal Investigator: Adamo Brancaccio, College of Pharmacy

    • Project Summary: Retrospective chart review of COVID positive patients to describe changes in warfarin dosage requirements. April 22

  26. ​Prognostication of COVID outcomes using sleep staging

    • Principal Investigator: Gita Gupta, Medical School 

    • We aim to use sleep as a biomarker to assess physiologic changes that lead to acute deterioration of hospitalized patients prior to the manifestation of clinical symptoms. April 22

  27. ECG Biomarkers in COVID-19 Patients

    • Principal Investigator: Jimo Borjigin, Medical School

    • People with pre-existing heart disease are more vulnerable to becoming severely ill with the coronavirus. It is yet unknown precisely what types of cardiac abnormalities are more common in COVID-19 patients. Dr. Borjigin is leading a research group, using electrocardiomatrix method invented in her lab, to report ECG abnormalities among ICU patients with COVID-19. April 22 

  28. Imaging findings and outcomes of Patients with Covid-19

    • Principal Investigator: Jadranka Stojanovska, Medical School

    • To develop a predictive model to risk-stratify patients at admission requiring ICU transfer, ETT placement, ECMO or experiencing death and identify Imaging signatures of obesity (subset of obese population) that predict hard outcomes. April 22

  29. Adult Respiratory Distress Syndrome Findings on chest X-ray

    • Principal Investigator: Jadranka Stojanovska, Medical School 

    • This project will be used as a comparison to identify any difference between ARDS COVID versus non-COVID. This project is a companion project to train the dataset for the predictive model. April 22

  30. Furin inhibitors to block SARS-Cov2 entry

    • Principal Investigator: Robert S. Fuller, Medical School

    • Project Summary:  I plan to send a variety of furin inhibitors (both small molecules and engineered proteins) that my lab developed with NIH support to researchers at UC Berkeley and other sites for testing in live virus infection assays. April 22

  31. Restarting safely: Point of care assessment of SARS-CoV-2 antibody and antigen response in a healthcare setting

    • Principal Investigator: Robert M. Eber, School of Dentistry

    • Project Summary: The University of Michigan School of Dentistry (UMSoD) will implement point of care antibody and antigen testing for SARS-CoV2 with a priority for asymptomatic frontline healthcare providers and essential workers. Our study, “Restarting safely: Point of care assessment of SARS CoV-2 antibody and antigen response in a healthcare setting”, will use an optional research questionnaire to collect demographic, exposure risk, quality of life, and testing results from subjects to determine the level of immunity to SARS-CoV2 in this population and answer many other questions related to risk determinants and impact of the disease. April 22 

  32. Determinants of Disease Severity in Coronavirus COVID-19 Infection presenting to Emergency Department

    • Principal Investigator: Prashant Mahajan, Medical School

    • Project Summary: We are proposing to study the host immune response in blood to SARS Co-V2 virus to investigate the pathobiology of COVID-19 and develop prognostication models based on perturbation of the host transcriptome. April 27

  33. A Comparative Study on the Effects of Angiotensin Receptor Blocker and Angiotensin Converting Enzyme Inhibitor use on the Severity of COVID-19 Infection

    • Principal Investigator: Nana Sefa, Medical School

    • Project Summary: We aim to use matching methods to determine the relationship between severity of COVID-19 infection and concurrent use of Angiotensin Converting Enzyme Inhibitors and Angiotensin receptor blockers to treat chronic hypertension. April 27

  34. CD8+ T cell responses and HLA-I genotypes in SARS-Cov2 infections

    • Principal Investigator: Malini Raghaven, Medical School /College of Lit, Science & Arts

    • Project Summary:  The goal of this project is to determine human leukocyte antigen genotypes in people with COVID-19 as well as in asymptomatic individuals.  April 27

  35. Priming of CD8+ T cell responses to SARS-CoV2

    • Principal Investigator: Malini Raghavan, Medical School LSA Biophysics/College of Lit, Science & Arts

    • CD8+ T cells are an important component of the immune response against viral infections. This project will develop procedures to identify and amplify CD8+ T cells specific to SARS-Cov2, the virus that causes COVID-19. April 2

  36. Discovery and characterization of antibodies for detecting and inhibiting SARS-CoV-2

    • Principal Investigator: Peter Tessier, College of Pharmacy / College of Engineering

    • Project Summary: Our project involves three components. First, we are using single-cell sorting methods for isolating monoclonal antibodies that are generated in response to different vaccine candidates in animal models (in collaboration with James Moon's lab at UM). Second, we are testing de novo designed peptides and antibodies for their ability to recognize the SARS-CoV-2 spike protein and neutralize the virus. Third, we are screening libraries of different types of antibody fragments for their ability to recognize the SARS-CoV-2 spike protein and neutralize the virus. Overall, these studies aim to define antibodies that potently recognize and neutralize the SARS-CoV-2 virus with the goal of accelerating therapeutic antibody and vaccine development. May 11 

  37. Mucosal vaccination for SARS-Cov2

    • Principal Investigator: James Baker Jr., Medical School

    • Project Summary: Pamela Wong The goal of this project is to develop vaccine candidates for SARS-Cov2 based on adjuvant combinations for improved immune responses and protection. May 11

  38. Association of Bedside Tracheostomy with Changes in Sedation During COVID-19: A Quality Improvement Evaluation at the University of Michigan and VA Ann Arbor

    • Principal Investigator: Theodore Iwashyna, Medical School / Institute for Social Research

    • Project Summary: We conducted a quality improvement project to assess whether tracheostomy reduced patients need for deep sedation under our routine practice at U-M. It did. May 13

  39. COVID-19 Expanded Access Program: Convalescent Plasma

    • Principal Investigator: Misty Gravelin, Medical School/MICHR

    • Project Summary: The U.S. Government is supporting a national Expanded Access Program to collect and provide convalescent plasma to COVID patients. Plasma from recovered COVID-19 patients contains antibodies that may help fight the disease. The Mayo Clinic will serve as the lead institution for the program, and the Michigan Institute for Clinical and Health Research is working closely with the Blood Bank to open a site for this research at U-M. The immediate goal of this research is to determine if convalescent plasma can improve the chance of recovery for people with the most severe disease. A second goal is to test whether convalescent plasma can help keep people who are moderately sick from getting sicker. Following registration on the protocol in one of the participating centers and provision of informed consent, patients will be given a transfusion with one unit of ABO-compatible convalescent plasma obtained from an individual who has recovered from documented infection with SARS-CoV-2. Safety information collected will include serious adverse events judged to be related to the administration of convalescent plasma. May 13

  40. A mutable vaccine for mutable viruses

    • Principal Investigator: Marilia Cascalho, Medical School

    • Project Summary: The research explores a vaccine, called the “mutable vaccine” for treatment (and with adaptations) for the prevention of disease by emerging mutable viruses. The mutable vaccine was originally designed with HIV in mind and therefore our discussion will be centered on HIV but our findings and the platform is clearly adaptable to other mutable viruses such as influenza, hepatitis C and SARS-Cov-2. Completely novel in concept and design, the mutable vaccine attacks mutable organisms like HIV by anticipating and immunizing against ongoing diversification of viral antigens and in doing so delays viral evolution enough to prevent viruses from escaping immune control. May 13 

  41. Chimeric Antigen Receptor (CAR)- Natural Killer (NK) cell Therapy for Acute SARS-CoV2 Infection.

    • Co-Principal Investigators: Venkat Keshamouni and Christine Basmajian, Internal Medicine/Pulmonary

    • Project Summary:  To develop CAR-NK cell therapy for COVID19 by targeting viral spike protein to selectively eliminate virus infected cells, prevent the formation of viral syncytia and promote viral clearance. May 29

  42. Rapid Drug Screening Protocol for COVID-19

    • Principal Investigator: Jonathan Sexton, Medical School

    • Project Summary:  U-M’s Center for Drug Repurposing is screening thousands of FDA approved drugs, clinical candidates and combinations thereof against SARS-CoV-2 in a bronchial airway viral infectivity assay. The goal is to identify and develop a rapidly deployable therapeutic intervention to combat Covid19. June 2

Educational Research and Practice

  1. Building a Strong and Equitable Mixed-Auspice Prekindergarten System (MAPS): A Research-Practice Partnership to Support Boston’s Historic UPK Expansion 

    • ​​Principal Investigator: Christina Weiland, School of Education

    • Project Summary: This project examines the expansion of the Boston prekindergarten model to community-based preschools. Preschool centers have been closed due to COVID-19 and we plan to document how the crisis affects them and the families they serve. March 31

  2. How People Learn Rapidly: COVID-19 as a Crisis of Socioscientific Understanding and Educational Justice and Equity

    • Principal Investigator: Angela Calabrese Barton, School of Education​​

    • Project Summary: This study investigates how people learn science during the COVID-19 pandemic in real time, and how they activate this scientific knowledge toward informed decision making, and how this changes over time. This study, which involves participants in Michigan and Washington, may serve a crucial role in aiding the public to understand where structural points of informational failure occurred, and may also reveal where and how individuals and families strengthened community action strategies to mitigate spread and suffering by gathering, sharing, and making sense of scientific data. April 2

  3. ​Detection of oral and nasal aerosols emissions during post-cardiac arrest cardiopulmonary resuscitation and electroconversion in COVID-19 patients

    • ​Co-Principal Investigators: Mohamad Hakam Tiba and Cindy Hsu, Medical School

    • Project Summary: This study investigates the potential of CPR or defibrillation to result in the generation of aerosol from the lung, and thus oral cavity, which could potentially expose providers to COVID-19. This is an important consideration for first responders and those providing bystander defibrillation using automated external defibrillators. April 3

  4. Incidence of bacterial pneumonia in COVID-19 + recipients of tocilizumab

    • Principal Investigator: Gregory Eschenauer, College of Pharmacy/Univ Hospitals & Health Center

    • Project Summary: The goal was to generally characterize secondary bacterial infections in patients who receive tocilizumab for the treatment of COVID-19 infection. April 13

  5. ​A novel peptide to accelerate anti-SARS-Cov-2 cellular immunity

    1. Principal Investigator: Marilia Cascalho, Medical School

    2. Project Summary: We hypothesize that anti-SARS-COV-2 cellular immune dysregulation is due to the early suppression of anti-viral CMI, mediated in part by innate T regulatory cells, contributing the dysregulated innate inflammatory response that ultimately causes death in many patients. We recently discovered that a soluble non-catalytic endproduct of complement activation - C3d accelerates and amplifies protective cell-mediated immunity (CMI) elicited by viral or by endogenous tumor antigens in part by inducing apoptosis of innate T regulatory cells [8]. We have been pursuing the use of C3d as a stimulus of CMI for cancer immunotherapy [8] but the challenge posed by SARS-COV-2 suggests there is an urgent need to explore potential application in control of SARS-COV-2 respiratory and cardiac complications of SARS-COV-2. April 13

  6. ​Preparedness and Response to COVID-19 – a Global Emergency Medicine Perspective

    • Principal Investigator: Prashant Mahajan, Medical School

    • Project Summary: We are conducting a global ED survey to collect data on individual site’s experience and response to the COVID-19 pandemic. Sharing lessons learned allows

      other EDs to leverage knowledge from their experiences, better understand disease epidemiology and plan for resource allocation that will benefit people and populations. April 13

  7. The Prenatal Support Project: Assessing Medical Students' Experience Counseling Pregnant Patients During COVID19

    • Principal Investigator: Alex Peahl, Medical School

    • Project Summary: During COVID-19 the Department of Ob/Gyn rapidly changed their approach to prenatal care. To provide patient support during this time, medical students were training to call patients and provide counseling and connect patients to resources. This project assesses medical students' experience during the project, and how skills learned can help develop their core competencies. April 13

  8. A study of teacher experience with online teaching in China during COVID-19 outbreak

    • Principal Investigator: Joey Wu, Rackham - Student

    • Project Summary: The COVID-19 Pandemic is having a profound impact on formal schooling in China. With the "suspended class, ongoing learning" policy issued, teachers in public schools have experienced a shift from traditional face-to-face teaching to online teaching. This study is proposed to investigate teachers’ experience with this shift at two middle schools in Hubei Province, China. Specifically, we are going to explore how online teaching takes place, teachers' experience, and teachers' perceptions of how their experience could be improved during the COVID-19 outbreak. April 15

  9. Assessing U-M Community's Library Needs during COVID-19 Outbreak

    • Principal Summary: Craig Smith, University Library

    • Project Summary: During a time when there is no access to physical U-M library buildings and collections, the University Library is surveying faculty (all tracks), graduate students, and undergraduates in order to understand how well we are meeting the needs of the academic community, and where we can adjust our remote services to be more a more effective academic partner.  April 17

  10. Accelerating Changes in Norms about Social Distancing to Combat COVID-19

    • Principal Investigator: Dean Yang, Institute for Social Research

    • Project Summary: The top priority for this project is to produce information that can directly inform the humanitarian response to COVID-19, and do so quickly. We intend to do so by 1) informing policymakers of their target population’s knowledge and behavior related to the disease, and 2) implementing novel interventions that aim to quicken changes in norms and improve behaviors relating to social distancing. April 17

  11. ICPSR's 2020 Data Resource Page

  12. ICPSR Working Paper 2: Best Practices for Measuring the Social, Behavioral, and Economic Impact of Epidemics

    • Principal Investigator: ICPSR at U-M ISR, ICPSR 

    • This report reviews best practices for using data resources from ICPSR, its projects, and its collaborating partners for measuring the impact of epidemics. The report summarizes resources to identify measures of well-being, social connectedness, and other constructs to measure the social and behavioral effects of the COVID-19 epidemic on population health outcomes. The report suggests data resources to identify pre-crisis measures of social distancing, social networks, consumer confidence, unemployment, and the use of social media. URL: https://deepblue.lib.umich.edu/handle/2027.42/154682 April 22

  13. COVID-19 Impacts on Psychiatric Emergencies

    • Principal Investogator: Ahmad Shobassy, Medical School

    • We are circulating a newly-designed survey in both PES and CES to learn about the impact of the pandemic on the mental health of adults and children presenting to both units. Later, a chart review will be conducted to explore potential correlations between certain diagnoses and demographic data and the pandemic impact on mental health. April 22

  14. Extubation readiness in intubated COVID-19 patients

    • Principal Investigator: Samir Gadepalli, Medical School

    • Project Summary: Assessing patients for readiness for liberation from mechanical ventilation is a complex critical care topic. Much work has been done to develop clinical findings, protocols, and metrics to assess the clinician in determining the risk of patients failing ventilator liberation. There have been several reports that in important ways coronavirus disease 2019 (COVID-19) does not behave in the way that traditional ARDS does. One way that this has manifested itself is that traditional metrics have been reported to poorly predict patients who may be able to be weaned from the ventilator. We aim to evaluate previously used and potentially novel metrics for ventilator liberation to provide clinicians with data to guide ongoing decision making. April 22

  15. Study on nursing-to-patient communication challenges

    • Principal Investigator: Arjun Adapa, Medical School

    • Project Summary: Healthcare workers can serve as vectors for the spread of infection, and current nursing models on most hospital floors require nurses to enter a patient's room multiple times for trivial requests (e.g. blankets, water) that may be able to be made using telemedicine strategies. To inform future developments of telemedicine strategies on hospital floors, we are conducting a survey of nurses and patients at the University of Michigan on nursing-to-patient communication challenges, areas of desired improvement, and the effects of current communication methods on medical error, COVID-related PPE use, and nurse safety. April 27

  16. K-12 Parent Experiences with Remote Learning During COVID-19

    • Principal Investigator: Elizabeth Keren-Kolb, School of Education

    • Project Summary: Dr. Kolb has put out two national surveys, asking K-12 teachers and parents on their experiences with remote learning during the COVID-19 pandemic. These surveys, one aimed at parents, the other at teachers, will be open until the end of May. The surveys are anonymous, all survey data will be de-identified before being shared. The survey responses will be used to inform professional development for K-12 school districts on developing blended and remote learning for learning continuity. The survey results will also provide a snapshot of both K-12 teachers and parents experiences with remote learning during COVID-19. It is vital that educational leaders understand teacher and parent perception and reaction to what they are being asked to do in this crisis, so we can better prepare blended learning professional development for Fall 2020. Each survey takes an average of 8 to 10 minutes to complete. April 27

  17. K-12 Teacher Experiences with Remote Learning During COVID-19

    • Principal Investigator: Elizabeth Keren-Kolb, School of Education

    • Project Summary: Dr. Kolb has put out two national surveys, asking K-12 teachers and parents on their experiences with remote learning during the COVID-19 pandemic. These surveys, one aimed at parents, the other at teachers, will be open until the end of May. The surveys are anonymous, all survey data will be de-identified before being shared. The survey responses will be used to inform professional development for K-12 school districts on developing blended and remote learning for learning continuity. The survey results will also provide a snapshot of both K-12 teachers and parents experiences with remote learning during COVID-19. It is vital that educational leaders understand teacher and parent perception and reaction to what they are being asked to do in this crisis, so we can better prepare blended learning professional development for Fall 2020. Each survey takes an average of 8 to 10 minutes to complete.  April 27

  18. Physician Leadership Experiences Responding to the COVID-19 Crisis

    • Principal Investigator: Taylor Standiford, Medical School

    • Project Summary:  The purpose of the study is to use video interviews of Michigan medicine leaders to explore key lessons, themes, and experiences that allow medical leaders to respond effectively during times of crisis, specifically the COVID-19 pandemic. We will create a manuscript informed by the interviews as well as a video presentation from clips of each interview that we will share with all Michigan medical students and the faculty leadership development department. April 28

  19. Understanding the Impact of the CoVid-19 Pandemic on Students and Healthcare Professionals

    • Principal Investigator: Dr. Roland Alexander Blackwood, Medical School

    • Project Summary: This project aims to assess how CoVid-19 has impacted communities by addressing questions about personal & professional life, education, access to services and mental health. The study will be adapted to 1) Addressing impact on healthcare workers on the frontlines 2) Addressing impact on underrepresented in medicine students, including undergraduates as well as health professional students. May 5

  20. Renal Insufficiency in Hospitalized patients with COVID-19

    • Principal Investigator: Samir Gadepalli, Medical School

    • Project Summary: Reports of renal insufficiency in patients with Novel Coronavirus SARS-CoV-2 who require hospitalization have been mixed, with some reports of low incidence of acute kidney injury and renal replacement therapy usage in this population. Despite this, our anecdotal experience in our institution has been that a relatively high proportion of hospitalized patients require active management of their fluid status due to renal insufficiency. We therefore aim to review our experience in this new population, to better quantify the impact of this disease. May 5

  21. The Impact of COVID-19 on the Student Experience - A Student Experience in the Research University (SERU) Survey Project

    • Principal Investigator: Annette Sieg,  Office of Budget & Planning Academic & Budget Affairs

    • Project Summary: This survey contains questions that are directly comparable to those in the regularly administered SERU survey on the University of Michigan campus ("UMAY") on students' education experience, sense of belonging and engagement as well as questions specific to the myriad potential impacts of COVID-19 on students' finances, health and well-being, future plans, and students' satisfaction with the institutional response to the COVID-19 pandemic. The goals of this survey project are to examine how differences in the COVID-19 impacted experiences of students relate to their intellectual, emotional, professional, and psychosocial development, and benchmark results against those of other research universities to support strategic planning and decision making, and inform higher education research, scholarship and policy. May 5

  22. Transition to Remote Learning in Linguistics

    • Principal Investigator: Kazuko Hiramatsu, Flint CAS

    • Project Summary: This study uses an online survey to explore the experiences of linguistics faculty and students in the U.S. during the transition to remote learning. The study goals are (1) to identify and assess the effectiveness of (frantic) mapping of learning activities/teaching strategies between face-to-face and remote learning modalities, and (2) to identify opportunities for growth in resources related to scholarly teaching for the Linguistic Society of America to focus on. May 13

  23. Impact of COVID-19 on Pre-Clinical Medical Student Online Testing and Virtual Learning Experience

    • Principal Inverstigator: Christian Vercler, MD, Medical School

    • Project Summary:  With the necessity of social distancing and nationwide shelter-in-place orders during the COVID-19 pandemic, most medical colleges have transitioned from in-person to virtual learning and test-taking.Our study aims to (1) assess pre-clinical medical student experiences with virtual learning and testing during the COVID-19 pandemic and (2) compare the ease of transition from in-person to virtual learning and test taking at different institutions, by administering a short survey to pre-clinical medical students enrolled in U.S. institutions. May 13

  24. Sofia Learns About Research

    • Principal Investigator: Lisa Connally, Medical School

    • Project Summary: A collaboration with the University of Buffalo exploring a coloring/workbook that is geared towards raising awareness and knowledge around clinical and health research for children and families. We would like to see if the book changes attitudes about participation in COVID-19 related research and will measure attitudes pre and post reading the book. This study will be conducted on-line, as there is a physical booklet, as well as an online interface. May 29

  25. Students’ mobility patterns on campus and the implications for the recovery of campus activities post-pandemic

    • Co-Principal Investigators: Quan Nguyen, Christopher Brooks and Daniel Romero, School of Information

    • Project Summary: Drs. Quan Nguyen, Christopher Brooks and Daniel Romero (School of Information) lead their team to understand how students use campus spaces and their mobility patterns, using network analysis. Their research will identify which student groups and which campus spaces are most vulnerable for infection, which are vital information as universities are planning to reopen the campus. May 29 

Effects of COVID-19 on Specific Populations

  1. Chinese People’s Communication and Health Behaviors during the COVID-19 Pandemic in the U.S.

    • ​​Principal Investigator: Hang Lu, College of Literature, Science, and the Arts

    • Project Summary: We conducted a two-wave survey among Chinese people currently living in the U.S. during the COVID-19 pandemic. With a special focus on alienation and stereotypes, we examined their media use, risk perceptions, beliefs, knowledge, attitudes, intentions and behaviors related to COVID-19. March 31

  2. COVID-19 and Older Adults: Perceptions, Behavior and Experience

    • ​​Principal Investigator: Brenda Whitehead, UM-Dearborn (College of Arts, Sciences, and Letters)

    • Project Summary: This study involves brief anonymous surveys distributed to U.S. older adults (aged 60+) intermittently over the course of the COVID-19 pandemic event. Surveys are designed to capture older adults' experiences during this event, with particular emphasis on factors contributing to stress and wellbeing during this time. Surveys are open for 48 hours at a time, and are therefore anchored to the historical and political events of the moment. Active surveys can be accessed via the Aging Well Lab website. March 31

  3. Household Influenza Vaccine Evaluation Study: COVID-19 response

    • ​​Co-Principal Investigators: Emily Martin and Arnold Monto, MD,  School of Public Health

    • Project Summary: The HIVE cohort is a longitudinal cohort of over 300 households with children in southeastern Michigan with year-round active surveillance of respiratory infections of any severity. This CDC and NIH-funded cohort, running since 2010, will be testing study specimens to evaluate the incidence of COVID-19 and transmission within the household setting, especially among people with mild illnesses that may not seek medical care. This team will be performing research use only RT-PCR and serology testing for influenza, COVID-19, and other respiratory viruses. April 2

  4. ​Rheumatology COVID-19 study

    • Principal Investigator: Beth Wallace​, Medical School

    • Project Summary: This is a provider-facing survey in which clinicians enter de-identified information about COVID-19 patients who have autoimmune conditions and/or take immunomodulatory medications. Data will be analyzed for relationships between disease state, medication exposure and outcomes such as hospital admission, ICU admission, intubation and death. March 31

  5. The Impact of the Coronavirus (COVID-19) Pandemic on Persons with Disabilities

    • Principal Investigator: Joshua Ehrlich, Medical School

    • Project Summary: This project will survey adults with various disabilities (physical, hearing, vision) and adults without disability to investigate the impact of COVID-19, and the societal response to COVID-19 on the daily lives of persons with disabilities; we will investigate the impacts on procuring food and medicine, work, transportation and economics. March 31

  6. ​​HARMONY - Home Activities and Routines Observed Naturally

    • Principal Investigator: Richard Gonzalez, Institute for Social Research

    • Project Summary: HARMONY is a study of the impact of COVID-19 on parenting and division of labor among co-parents with very young children. April 3

  7. ​Patient perspective in a time of uncertainty for transplantation due to COVID-19

    • ​Principal Investigator: Seth Waits, Medical School

    • Project Summary: By providing phone surveys to patients who are awaiting organs on the transplant list, we hope to better understand their knowledge base regarding COVID-19, fears of being on the waitlist/being transplant during the COVID-19 crisis and design interventions to better assist them through the process. April 6

  8. ​​COVID-19 Response Amendment to Orphans and Vulnerable Children

    • ​​Principal Investigator: Dean Yang, Ford School of Public Policy/College of Lit, Science & Arts
      Institute for Social Research

    • Project Summary: In partnership with the Mozambican government, we week to provide rapid assessment of COVID-19-related knowledge, beliefs, and protective behaviors, and seek to accelerate changes in norms of social distancing. April 7

  9. Study of Adolescent to Adult Neural Development - Brief Check-In

    • Principal Investigator: Christopher Monk, Medical School/College of Lit, Science & Arts
      Institute for Social Research

    • Project Summary: We propose to acquire survey data via the internet or phone to assess the health (physical and mental) and economic circumstances of an existing sample of predominantly lower income subjects during the COVID-19 crisis. The participants are part of the Fragile Families and Child Wellbeing study, which is a longitudinal study of participants who have been followed since birth and they are now about 21 years of age. April 7

  10. ​​A Barometric Survey of COVID-19's Impacts on Entrepreneurs

    • ​​Prinicipal Investigator: Felichism Kabo, Institute for Social Research/SRC-Social Envir & Health

    • Project Summary: The COVID-19 pandemic is having heavy and unprecedented impacts on entrepreneurs and small businesses across the nation, and it is imperative that we collect data on how COVID-19 is currently impacting entrepreneurs in order to position us to better address the short- and long-term effects of COVID-19 on the national economy. We plan to do this by administering a COVID-19 supplemental survey to the nationally representative Understanding America Study (UAS) internet panel in the summer of 2020. April 7

  11. COVID-19 in Heart Transplant Recipients: a case series

    • ​​Principal Investigator: Scott Ketcham, Medical School

    • Project Summary: Our project goal is to describe the clinical manifestations, course and outcomes among adult heart transplant recipients admitted with covid-19 infection. April 9

  12. USA Pediatric COVID-19 Registry

    • Principal Investigator: Jason Weinberg, MD, Medical School

    • Project Summary: We will be contributing data to a multi-center study organized by the Pediatric Infectious Diseases Transplant Network through its Coordinating Center at St. Jude Children’s Research Hospital. This goal of this study is to describe the epidemiology, clinical presentation, and outcomes of pediatric patients with COVID-19 across the United States. April 13

  13. The effect of COVID-19 on medical cannabis patients: access, use, and perceptions

    • Principal Investigator: Kevin Boehnke, Medical School

    • Project Summary: This survey project will examine how the COVID-19 pandemic has affected individuals using medical cannabis, with specific focus on consumption patterns, access to cannabis products, and use of other medications during the COVID-19 pandemic. April 13 

  14. ​​Older adult medication decisions during COVID-19

    • Principal Investigator: Sarah Vordenberg, College of Pharmacy

    • Project Summary:  The primary objective of this study is to identify whether older adults with chronic health conditions such as cardiovascular disease, lung disease, or diabetes (i.e. high risk patients) will avoid going to the pharmacy to obtain their chronic medications due to the risk of COVID-19. April 14

  15. ​​Impact of Pre-existing Sleep Disorders on Response to COVID-19 Infection

    • Principal Investogator: Helen Burgess, Medica School 

    • Project Summary: This project aims to determine if the pre-existing severity and treatment of obstructive sleep apnea influences the disease course after hospitalization for COVID. April 15

  16. Outcomes of COVID19 infection in solid organ transplant candidates and recipients

    • Principal Investigator: Pratima Sharma, Medical School

    • Project Summary: The objective of this project is to define the predictors of favorable and unfavorable outcomes in solid organ transplant recipients. April 17

  17. Racial minorities social psychological coping with covid

    • Principal Investigstor: Muniba Saleem, Communications and Media

    • Project Summary: Examine the differences in racial majority and minority members' social psychological reactions to covid. April 22

  18. SURVEY05 Spiromics II

    • Principal Investigstor: MeiLan Han, Medical School

    • Project Summary: This will be blood for covid antibodies, a CT scan of the chest and covid questionnaire added to a COPD cohort study. April 22

  19. Cultural contexts, age, and decision making in the Coronavirus Pandemic

    • Principal Investigator: Twila Tardif, College of Lit, Science and Arts

    • Project Summary: Our goal is to understand how to increase the likelihood that an individual will make and maintain the choice to “socially distance” themselves, particularly from contacts that are seen as pleasurable and as helping them maintain psychological health in the midst of a crisis. We will do this by examining a range of adults across several countries, and conducting a mini-experiment involving visualizations in the middle of a questionnaire about social distancing choices, anxiety levels, and various measures of trust in government and other sources of information about COVID-19. April 22

  20. Strengthening Flint Families

    • Principal Investigator: Sarah Stoddard, Flint, School of Nursing

    • Project Summary: As part of an ongoing community-based, multilevel intervention designed to reduce behavioral health disparities, we will conduct semi-structures phone interviews with peer recovery coaches to examine the impact of COVID-19 on recovery coaches - including barriers and facilitators of service delivery - in Flint. April 22

  21. SURVEY01 Asthma experience during the COVID-19 pandemic

    • Principal Investigator: Alan Baptist, Medical School / School of Public Health

    • Project Summary: Individuals with asthma are being told conflicting messages by physicians, news media, and governmental agencies. This survey-based study will examine patient and physician attitudes, behaviors, and management strategies over time. April 22

  22. University of Michigan COVID-19 Cancer Consortium (CCC19) Registry

    • ​Principal Investigator: Christopher Friese,  School of Nursing / Svchool of public Health

    • Project Summary:There is an urgent need to characterize the patterns, correlates, and outcomes of adults with cancer who contract the novel coronavirus SARS-CoV-2 and the associated illness (COVID-19). The University of Michigan Rogel Cancer Center will participate in the multinational COVID-19 and Cancer Consortium. This project will characterize the patient characteristics, course of illness, treatment modalities, and outcomes of adult patients with a cancer diagnosis and documented or suspected SARS-CoV-2 infection. April 22  

  23. SURVEY11 COVID: Older Adults and Social Engagement during Social Distancing

    • Principal Investigator: Robin Brewer, Sc hool of Information 

    • Social distancing measures required due to the COVID-19 pandemic are affecting the ways in which people communicate and engage socially with others offline and digitally. This change is particularly affecting the older adult (65+) demographic, which has been listed as a high-risk demographic. Although helpful, these social distancing measures may be further affecting a demographic already at-risk for social isolation. Simultaneously, older adults may have adjusted their social engagement routines through means such as family video conferencing or increased communication with friends.The goal of this project is to understand older adult's interpersonal social engagement patterns/changes as a result of COVID-19. April 22

  24. SURVEY14 Function and Wellbeing of People with Scleroderma during Covid-19 Pandemic: Follow-up with REACH participants

    • Principal Investigator: Susan Murphy, Medical School

    • Project Summary: This study involves interviewing participants with scleroderma about their physical and emotional wellbeing during the Covid-19 pandemic. April 22

  25. Maternal Health and Sleep During Covid-19

    • Principal Investigator: Louise O'Brien, Medical School/School of Dentistry 

    • Project Summary: This global survey aims to explore the experiences, healthcare, and support networks, as well as sleep patterns, of pregnant women and women who have lost a baby. April 27

  26. Patient and Provider Perspectives of Telemedicine Implementation during COVID Pandemic on Prenatal Care

    • Principal Investigator: Alex Peahl, Medical School

    • Project Summary: The Ob/Gyn Department rapidly implemented telemedicine as a part of prenatal care to balance the need for in-person care with the risk of COVID-19 exposure. This study is a retrospective assessment of the perspectives of pregnant patients and prenatal care providers about the changes in prenatal care and implementation of telemedicine. May 5

  27. Stay Home, Stay Connected: Online Virtual Pregnancy Support Group During the COVID-19 Pandemic

    • Principal Investigator: Alex Peahl , Medical School

    • Project Summary: During the COVID-19 pandemic, the department of Ob/Gyn rapidly redesigned prenatal care to included fewer overall visits and more virtual care. To provide additional support during this time, we started an online pregnancy support program to give patients the opportunity to connect with other pregnant patients and providers. We plan to assess the feasibility and acceptability of this pilot program. May 5

  28. Physicians and asthma management during COVID-19

    • Principal Investigator: Alan Baptist, Medical School /  School of Public Health

    • Project Summary: The survey is of physicians who take care of asthma patients. We are trying to determine how COVID-19 is changing asthma management for patients and providers. May 13

  29. Patient Perceptions on Transition from Ambulatory Center Infusions to Home Infusions for Inflammatory Bowel Disease Patients During the COVID-19 Pandemic: A Qualitative Quality Improvement Study

    • Co-Principal Investigators: Jeffrey Berinstein/Peter Higgins, University Hospitals & Health Center

    • Project Summary: We plan to explore the effects of the COVID-19 pandemic on infusion scheduling for IBD patients in order to understand the strengths, weaknesses and barriers to increased uptake of home infusions compared to the traditional clinic or hospital based infusions. May 13 

  30. Quality of Life in Older Adults with Hearing Loss Secondary to COVID-19 Precautions

    • Principal Investigator: Rachel Fryatt, AuD, Univ Hospitals & Health Center

    • Project Summary: Identify the social impact of restrictions secondary to COVID19 pandemic, and identify differences in these perceptions in those who utilize hearing devices and those who do not. There is evidence to suggest that those with hearing loss are susceptible to social isolation, depression, and cognitive impairment, and the utilization of a hearing aid may reduce these effects; I am interested to see if the pandemic precautions affect those who wear hearing devices differently compared to older adults who do not. May 13 

  31. Binding Research to Advance Transmasculine Health (BREATHE)

    • Principal Investigator: Sarah Peitzmeier, School of Nursing

    • Project Summary: We are interviewing transmasculine and/or nonbinary individuals who practice chest binding about the effects the pandemic and stay-at-home orders have had on the way they practice chest binding and the health symptoms they experience as a result of binding. May 29

  32. Understanding Young Adult Cancer Patients’ Psychosocial Concerns Related to COVID-19

    • Principal Investigator: Nick Iannarino,  Dbn Col of Arts, Sci & Letters

    • Project Summary: Through semi-structured interviews, we plan to learn how young adult (YA) cancer patients and survivors aged 18-35 are experiencing and managing psychosocial challenges related to COVID-19 and cancer. We will evaluate how YA cancer patients and survivors have experienced changes in their communication with healthcare providers (e.g., evaluating their use of telemedicine with oncologists and primary care physicians; examining their experience of face-to-face health consultations). We also seek to understand how YA cancer patients' and survivors’ communication with existing or potential support networks has changed.  May 29

Effects of the Pandemic on Healthcare Workers, Delivery and Policy

  1. Effect of COVID19 isolation regulations on Sleep and Health in a sample Health Care Workers in the Midwest United States

    • Principal Investigator: Deirdre Conroy, Medical School

    • Project Summary: The aim of this study is to collect survey data from a sample of health care workers in the midwest U.S. This descriptive study will assess how sleep, health and working behaviors changed during this time of isolation. March 31

  2. ​Availability of ICU resources in response to COVID-19 pandemic

    • ​​Principal Investigator: Tom Valley, Medical School

    • Project Summary: We are surveying ICU administrators in the state of Michigan to understand how they’ve prepared for the COVID-19 pandemic and how they feel about these preparations. We are also conducting textual analysis on policies/guidelines obtained from these administrators. March 31

  3. ​​Impact of the COVID Outbreak on Stroke Preparedness

    • Principal Investigator: Lesli Skolarus, Medical School

    • Project Summary: Through longitudinal telephone interviews, we seek to understand the changing perceptions of seeking emergency stroke care and maintenance of a healthy lifestyle during the Coronavirus outbreak. This qualitative study will be conducted in Flint, Mich. March 31

  4. Healthcare Workforce Capacity

    • Principal Investigator: Angela Beck, School of Public Health

    • Project Summary: As the number of COVID-19 cases continues to rise, the capacity of the health care system to treat cases is being tested in many cities as concerns mount over availability of hospital beds and needed supplies. Concurrently, the frontline health care workforce is being strained due to inadequate personal protective equipment, which has the potential to lead to widespread illness and understaffing. The need for mental health providers is also expected to sharply increase. There is an urgent need for licensing regulations and educational requirements to be modified to support workforce flexibility and surge capacity. April 2​

  5. ​​US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN)

    • Co-Principal Investigators: Emily Martin and Arnold Monto, MD,  School of Public Health 

    • Project Summary: This CDC-funded study conducts active surveillance for acute viral respiratory illness across among adults hospitalized across 4 study center in the US (active since 2015). The UM team works in conjunction with the CDC to conduct this study in 3 hospitals in southeast Michigan. For the COVID-19 pandemic, this team will be collecting in-depth data on the clinical course and outcomes of hospitalized patients with COVID-19 for national-level analyses led by CDC. April 2

  6. ​Michigan-Ford Influenza Vaccine Effectiveness (MFIVE) Study - Part of the CDC US Flu VE Network

    • ​​Co-Principal Investigators: Emily Martin and Arnold Monto, MD,  School of Public Health

    • Project Summary: This CDC-funded study works in partnership with other national sites to conduct active surveillance of individuals with medically-attended acute respiratory illness (active since 2010). The UM teams works with 12 ambulatory clinics across southeast Michigan to collect data on viral illnesses. Along with the CDC, this team will be collecting self-swabs and clinical data to evaluate the epidemiology, clinical characteristics, and risk factors for COVID-19 across the U.S. April 2

  7. Household Influenza Vaccine Evaluation Study: COVID-19 response

    • ​​Co-Principal Investigators: Emily Martin and Arnold Monto, MD,  School of Public Health

    • Project Summary: The HIVE cohort is a longitudinal cohort of over 300 households with children in southeastern Michigan with year-round active surveillance of respiratory infections of any severity. This CDC and NIH-funded cohort, running since 2010, will be testing study specimens to evaluate the incidence of COVID-19 and transmission within the household setting, especially among people with mild illnesses that may not seek medical care. This team will be performing research use only RT-PCR and serology testing for influenza, COVID-19, and other respiratory viruses. April 2

  8. ​​Functional and Neurologic Outcomes of COVID-19

    • ​Principal Investigator: Alecia Daunter, Medical School

    • Project Summary: This is a single center study to prospectively monitor for functional changes and neurologic issues related to the current COVID-19 pandemic. The information obtained in this analysis will be helpful to better prepare our own health system, and health systems around the world, for post-acute and rehabilitative needs of patients affected by this novel virus. March 31

  9. Hospital-Associated Respiratory Virus Infections Molecular Epidemiology, Clinical Outcomes, and Cost-Effectiveness of Interventions​​

    • Principal Investigator: Joshua Petrie, School of Public Health

    • Project Summary: The goals of this existing research project are to determine the overall impact of hospital-associated respiratory virus infections, improve case-definitions for their identification through integration of epidemiological and molecular data, and develop models to predict the most effective interventions for their prevention. This research will be applied to COVID-19 which has resulted in notable healthcare associated outbreaks. April 3

  10. Availability of ICU resources in response to COVID-19 pandemic

    • ​​Principal Investigator: Tom Valley, Medical School

    • Project Summary: We are surveying ICU administrators in the state of Michigan to understand how they’ve prepared for the COVID-19 pandemic and how they feel about these preparations. We are also conducting textual analysis on policies/guidelines obtained from these administrators. April 3

  11. ​Centering Health Equity in the Rapid Virtualization of Health and Social Care during the COVID-19 Pandemic

    • ​​Principal Investigator: Tiffany Veinot, School of Information

    • Project Summary: The overall goals of the study are: (1) to assess health equity impacts of the rapid transition to online delivery of health and social care services in the face of the COVID-19 pandemic; and (2) to develop and evaluate approaches to providing support to patients to enhance equitable access, uptake and engagement with this form of health and social care delivery. April 6

  12. Acceptability, Usability & Efficacy of Tele-Mental Health Group Interventions for Trauma-exposed Psychiatric Patients and Frontline Healthcare Providers During COVID

    • ​​Principal Investigator: Anthony King, Medical School/Institute for Social Research

    • Project Summary: Responsive to safety measures for COVID, Michigan Medicine is shifting psychotherapy services as possible to tele-mental health / “video visits”. We will collect program evaluation data on the acceptability, usability and efficacy of tele-mental health group psychotherapies for trauma and stress exposures in three ad hoc clinical cohorts: (i) PTSD patients (N=15) currently enrolled in an RCT of 8-week Mindfulness-based Cognitive Therapy (MBCT) vs relaxation therapy (PMR); (ii) psychiatric patients with anxiety and/or depression enrolled in an 8-week MBCT group offered by MM Psychiatry, and (iii) a 4-week group therapy program to be offered by MM Psychiatry (“Tools for Managing Anxiety from COVID-19”). April 6

  13. Michigan Hospital Medicine Safety (HMS) Consortium - COVID-19

    • ​​Principal Investigator: Scott Flanders, Medical School

    • Project Summary: Using the Blue Cross Blue Shield of Michigan (BCBSM) Collaborative Quality Initiative (CQI) infrastructure, the Michigan Hospital Medicine Safety (HMS) Consortium, along with other CQIs, is launching a new quality improvement initiative related to patients tested for COVID-19 in hospitalized patients. Hospitals currently participating in the CQIs across Michigan will be contributing data, including patient signs/symptoms, co-morbid conditions, medical history, course of treatment and post discharge information. The goal of the initiative is to identify best practices and strategies related to the identification, testing and treatment of COVID-19 to provide better care to patients with COVID-19. De-identified summary data will be provided back to each hospital. This is retrospective data collection.March 31

  14. Home Health Nurses Experiences Caring for Older Adults in a Disaster

    • ​​Principal Investigator: Sue Anne Bell, PhD, FNP-BC, School of Nursing

    • Project Summary: The goal of this project is to better understand how the COVID-19 pandemic impacts older adults’ longitudinal chronic disease trajectories in order to develop and promote effective patterns of care during large-scale disasters. We aim to uncover strategies that support preservation of function for older adults during a disaster by interviewing home-based care providers – practitioners that have a unique insight into disaster response at the community level – about their care-giving experiences during and after the COVID-19 pandemic. April 7

  15. ​Estimating workforce demand for mental health services during/post-COVID-19

    • Principal Investigator: Angela Beck, School of Public Health

    • Project Summary: As a result of the COVID-19 pandemic, an understaffed and maldistributed behavioral health workforce must prepare for the spike in mental health needs known to occur during and after a crisis. As businesses aim to reopen in the coming months, worker wellness and productivity are likely to be impacted by behavioral health factors. Meanwhile, frontline health care workers and first responders are already experiencing acute mental health needs. This study will estimate the workforce surge needed to deliver mental health and substance use disorder services and provide recommendations to employers for supporting the behavioral health needs of staff in the workplace. April 12 ​​

  16. USA Pediatric COVID-19 Registry

    • Principal Investigator: Jason Weinberg, MD, Medical School

    • Project Summary: We will be contributing data to a multi-center study organized by the Pediatric Infectious Diseases Transplant Network through its Coordinating Center at St. Jude Children’s Research Hospital. This goal of this study is to describe the epidemiology, clinical presentation, and outcomes of pediatric patients with COVID-19 across the United States. April 13

  17. ​Increasing Access to Health Care for Black Men: The Michigan Men's Health Event

    • Principal Investigator: Jaclynn Hawkins, School of Social Work

    • Project Summary: The goals of this project are 1) To advance our understanding of the impact of a free men's health event on help-seeking and health behaviors in men and 2) To further our understanding of the health care needs and health behaviors of men during the Covid-19 pandemic. This study will use semi-structured interview techniques with a predominately low-income African American sample of men residing in the City of Detroit.  April 13

  18. Nurses Coping with Caregiving During Covid19

    • Principal Investigator: Sheria Robinson-Lane, School of Nursing

    • Project Summary: A qualitative study that explores the experiences of nurses providing care during a pandemic. I am interested in the ways that nurses are adapting to the changing healthcare environment. April 13

  19. Development of pandemic control strategies that are economically and socially sustainable

    • Principal Investigator: Santiago Schnell, Medical School

    • Project Summary: In this project, Yonatan Savir (Technion, Israel) and Santiago Schnell (University of Michigan, USA) are developing mathematical and computational models to identify control pandemic strategies that save lives using a more economically and socially sustainable approach than the current COVID-19 global lock down. April 13

  20. SURVEY04 Evaluate the Incidence, Perceptions, and Identified Barriers of Burnout in Health-System Pharmacists during COVID19 Pandemic

    • Principal Investigator: Rima Mohammad, College of Pharmacy

    • Project Summary: This study will seek to understand the incidence, perceptions and barriers of burnout in health-system pharmacists and to understand the needs required to properly address burnout in these pharmacists during the COVID19 pandemic. April 22

  21. Telemedicine Quality Assessment During the Coronavirus Pandemic

    • Principal Investigator: Paula Anne Newman-Casey , Medical School

    • Project Sumnary: The objective of our study is to asses patient's experience with eye care during the COVID 19 pandemic, whether the care was delivered in-person, via telemedicine or whether care was deferred. April 22

  22. SURVEY03 Improving team dynamics during COVID-19

    • Principal Investigator: Deena Kelly Costa PhD, RN, School of Nursing

    • Project Summary: We are conducting a quality improvement project in Michigan Medicine ICUs to determine how to improve how teams work together during COVID-19. Since staff are redeployed from all units in the hospital, and forming/reforming frequently, we are conducting interviews with ICU clinicians to determine what team and organizational activities can be done to improve team dynamics. April 22

  23. Clinician Experiences with Family Meetings Regarding Initiating Dialysis in Critically Ill Patients

    • Principal Investigator: Kunal Bailoor, Univ Hospitals & Health Center

    • Project Summary: Family meetings in the ICU around the question of dialysis, particularly in the era of the COVID-19 pandemic, can be fraught with angst and conflict. We hope to better understand the factors that drive this by interviewing clinicians involved in these meetings. April 27

  24. ​Health and Retirement Study

    • Principal Investigator: David Weir, Institute for Social Research

    • Project Summary: The Health and Retirement Study, a nationally representative longitudinal study of older Americans begun in 1992, will add to its ongoing 2020 telephone interviews a set of questions on experience with COVID-19 and the impact of the pandemic and mitigation policies on health care, work, and family.  April 27

  25. Novel Use of Pediatric Nurse Practitioners in the Adult Respiratory Care Unit during the Sars-CoV-2 Pandemic

    • Co-Principal Investigators: Janella Reske, Christine Renke, Blythe Pollack, Tara Egnor, Natalie Hecht, Kim Kellogg, Louise Callow, Chelsea Honstain, Andrea Kline; Univ Hospitals & Health Center - All PI's School of Nursing/Univ Hosp & Health - Andrea Kline

    • Project Summary: Retrospective summary of the utilization of Pediatric Nurse Practitioners as Providers in an Adult COVID-19 ICU. Exploration of patient population, barriers, lessons learned, and recommendations for future pandemic planning.  May 13

  26. Interprofessional Collaboration in the Midst of the Covid-19 Pandemic: Perspectives from Inpatient Physical Therapists and Occupational Therapists

    • Principal Investigatgor: Amy Yorke, Flint College Health Sciences

    • Project Summary: The purpose of this longitudinal qualitative research study is to explore the experiences of interprofessional collaboration among physical therapists and occupational therapists who continued to work in an inpatient setting during the Covid-19 crisis. May 29

Epidemiological, Social and Behavioral Research

  1. Changing perceptions of countermeasures to a novel coronavirus

    • Principal Investigator: Abram Wagner, School of Public Health

    • Project Summary: Adults in China and the U.S. are being surveyed about the ongoing COVID-19 outbreak, including their perceptions of getting infected, their acceptance of a COVID-19 vaccine, and whether or not they were socially distancing. Over time, more surveys will be distributed to identify how changes in the epidemiology of disease affect these behaviors. March 31

  2. COVID-19 and compassion beliefs

    • ​​Principal Investigator: Julia Lee Cunningham, Ross School of Business

    • Project Summary: Examine people’s beliefs about compassion (as a limited resource vs. unlimited) and how it influences their behavior in response to COVID-19. March 31

  3. COVID-19 and beliefs on human nature

    • Principal Investigator: Julia Lee Cunningham, Ross School of Business

    • Project Summary: Study how people’s narratives around crisis situation makes them more or less selfish influences their behavior. March 31

  4. ​​A Study on Beliefs about Eating and Drinking #2

    • ​​Principal Investigator: Ashley N. Gearhardt, College of Literature, Science, and the Arts

    • Project Summary: We are investigating whether COVID-19 may be impacting dietary intake, alcohol consumption, addictive eating behavioral and a tendency to use food and alcohol to cope. We are also interested in investigating whether there may be differences in these behaviors by participants' perceived vulnerability to disease, their political orientation and the state they reside in. March 31

  5. ​Life Perspectives Survey

    • Principal Investigator: Kevin F. Miller​​, College of Literature, Science, and the Arts/School of Education/Institute for Social Research

    • Project Summary: An open-ended survey on how student lives, perspectives and learning experiences have been affected by the COVID-19 pandemic and its disruption of traditional educational practices. April 1

  6. Organizational Adaptation in Crisis: A Case Study of a Community Lab's Response to COVID-19

    • ​Principal Investigator: Hilary Hendricks, Ross School of Business

    • Project Summary: My dissertation documents how workers in an independent lab in Bellingham, Wash., rapidly and creatively developed COVID-19 testing capability in an environment marked by scarcity and fear. Studying leaders' and workers' experiences as the crisis unfolds may yield insights that can help other organizations respond more flexibly to rapidly evolving situations. April 2

  7. ​PETAL COVID-19 Observational Study

    • ​​Principal Investigator: Theodore J. Iwashyna, Medical School/Institute for Social Research

    • Project Summary: This national epidemiological cohort will measure the patterns of recovery of cardio-pulmonary, physical, cognitive, emotional and social function among patients with COVID, understanding both their own healing process over time, and how it affects their caregivers and family. April 2

  8. ​Epidemiological modeling for COVID-19 response

    • Principal Investigator: Marisa Eisenberg, School of Public Health

    • Project Summary: This project is focused on developing transmission models for COVID-19 to assist in understanding and forecasting epidemic spread and hospital resource needs, and to examine scenarios regarding social distancing and other interventions. The model is calibrated based on Michigan data on COVID-19 testing and demographics, as well as Michigan and other literature data on disease progression, severity, mortality, and other disease features. The researchers have been working together with the Michigan Department of Health and Human Services to provide tools to help inform planning and response efforts. April 3

  9. Disease Concealment of COVID-19

    • ​​Principal Investigator: Wilson Merrell, College of Literature, Science, and the Arts

    • Project Summary: In our project we are exploring the psychological underpinnings of disease concealment by measuring motivations and tradeoffs that people experience in the face of disease threats. Despite the fact that treatment is often the ideal both at the individual and group level in terms of curing infectious disease, people often report trying to cover up signs of their illness -- e.g. stifling coughs, wearing extra makeup/deodorant -- either instead of or in addition to treatment. April 3

  10. ​​Science and Rumor of/as Virus: the Politics of Information Legitimacy of COVID-19 during the Early Outbreak in China

    • ​​Principal Investigators: Yuchen Chen, Alex Jiahong Lu and Hailey Youngrim Kim, College of Literature, Science, and the Arts/School of Information

    • Project Summary: Our project investigates 1) the production and dissemination of scientific knowledge and “rumors” of COVID-19 and 2) the construction and politics of authoritative/credible voices of COVID-19 during its early outbreak in China. April 6

  11. ​​​Rapid COVID-19 Detection at Global Scale

    • ​​Principal Investigator: Kwame Porter Robinson, School of Information

    • Project Summary: An initial position paper that calls for more Artificial Intelligence (AI) research into a specific, but neglected class of detection as highlighted through an original typology of covid19 detection. This class of detection research is motivated by the success of Italy's covid19 experiment in Vò, Italy, where Coronavirus spread was completely stopped by total and simultaneous testing, and presented as an original engineering problem requiring AI to overcome traditional limitations in signal detection theory. April 6

  12. An Epidemiological Forecast Model and Software Assessing Interventions on COVID-19 Epidemic in China

    • ​Principal Investigator: Peter Song, School of Public Health

    • Project Summary: We develop a health informatics tool enabling analysis and evaluation of a range of infectious disease epidemics. As a case study, we examine the COVID-19 epidemic using publicly available data from China’s CDC. The tool is built on established infectious disease models. We extend the model to incorporate various time-varying quarantine protocols, including large-scale, government-level isolation policies and local community-level social distancing measures. We account for underreporting of infected cases. The tool provides forecasts of the disease’s spread and simulates the overall dynamics of the epidemic. A software package is available for public download and includes tutorials. April 2

  13. CLINICAL TRIAL Propofol-Associated Hypertriglyceridemia in COVID-19 versus Non-COVID-19 Critically Ill Patients

    • ​​Principal Investigator: Michael Kenes, College of Pharmacy

    • Project Summary: This study seeks to characterize the incidence of and risk factors for development of propofol-associated hypertriglyceridemia in patients requiring sedation for management of COVID-19 ARDS compared to non-COVID-19 ARDS. April 7

  14. ​Intern Health Study

    • Principal Investigator: Srijan Sen, Medical School/College of Lit, Science & Arts/UMOR MI Inst for Data Science/UMOR Advanced Research Computing/UMOR Office of VP for Research

    • Project Summary: Building on the ongoing Intern Health Study, we are assessing the risk exposure, work demands and physical and mental health of 1500 training physicians with the COVID-19 outbreak and the potential of mobile technology to track disease spread. April 13

  15. COVID-19 and biodiversity

    • Principal Investigator: Julia Lee Cunningham, Ross School of Business

    • Project Summary: Study how people’s attributions of COVID-19 influences their attitudes and support for policies relating to biodiversity and climate change. April 13

  16. ​​Statistical estimation of time-varying transmission and removal rates in epidemiological processes: an application to the COVID-19 pandemic

    • Principal Investigator: Yi Li, School of Public Health

    • Project Summary: We propose a Poisson model with time-dependent transmission and removal rates. The Poisson model can capture the possible random error in reporting. Simulations have confirmed the utility of the proposal. We apply our method to study the pandemic in the most severely impacted countries, and analyze and forecast the evolving pandemic. April 13

  17. Sex in the time of COVID-19

    • Principal Investigator: Rob Stephenson, School of Nursing

    • Project Summary: “Sex in the time of Covid-19” seeks to understand how the Covid-19 pandemic has shaped sexual risk behavior and engagement in HIV prevention and care among gay, bisexual and other men who have sex with men in the U.S. The project will collect an online national sample of approximately 2000 men, surveying their recent sexual and other HIV risk behaviors. A follow-up survey in 6 months will assess changes in behaviors among the sample.  April 13

  18. A first look at COVID-19 information and misinformation sharing on Twitter

    • Principal Investigator: Ceren Budak, School of Information (With collaborators across multiple universities)

    • Project Summary:  we are examining Twitter content pertaining to COVID19 and studying temporal, geographical, and language trends. We also examine the quality of information shared on Twitter. Pre-print of first look at: https://arxiv.org/abs/2003.13907 April 13

  19. ​​Parents' Perceptions of Children's Responses to News of COVID-19

    • Principal Investigator: Kristen Harrison, College of Lit, Science & Arts Institute for Social Research

    • Project Summary: This project is a survey of children's fright reactions to news about COVID-19 as reported by parents. The analytical goal is to identify the most frightening stimuli and most effective coping strategies by developmental stage to advise parents on effective coping strategies for children of different ages.  April 13

  20. Excess Mortality from COVID-19: Lessons Learned from the Italian Experience

    • Principal Investigator: Paolo Pasquariello, Ross School of Business

    • Project Summary: There is much discussion among clinicians, epidemiologists, and public health experts about why case fatality rate from COVID-19 in Italy (at 12.1% as of April 2, 2020, versus a global case fatality rate of 5.2%) is considerably higher than estimates from other countries (especially China, South Korea, and Germany). In this article, we propose several potential explanations for these differences. April 13

  21. Developing and Innovating Operations Research and Industrial Engineering Tools for COVID-19 Related Problems

    • Principal Investigator: Siqian Shen, College of Engineering

    • Project Summary: In the midst of the COVID-19 pandemic, policymakers, companies, community workers and individual households have been designing new systems and procedures to fight the virus. Many problems related to optimizing these systems and their operations can be tackled by extending the traditional OR and IE approaches with new objectives, constraints, and input data. The purpose of this talk is to summarize potential scenarios one may encounter during the prevention, disease control, intervention and recovery phases during COVID-19 outbreaks, and develop OR and IE tools that can be applied for solving the related problems. April 13

  22. ​​The Impact of COVID-19 on Norms, Risk-taking, Information, and Trust

    • Principal Investigator: Erin Krupka, School of Information 

    • Project Summary: Governments and health organizations provide extensive information and recommend behavior to avoid contracting the disease and spreading it to others. In this project we exploit previous samples of subjects recruited under two prior NSF-supported projects to test the impact of the information and recommendations on behavior, social norms, trust in each other and institutions, and risk-tolerance. April 14

  23. ​Inflammatory Biomarkers and Outcomes of Patients with Covid-19

    • Principal Investigator: Salim Hayek, Medical School

    • Project Summary: Adequate triage of the large influx of Covid-19 is essential to avoid overwhelming healthcare resources. Our traditional clinical assessments are ineffective in differentiating between patients who remain stable and those who will progress to respiratory failure and require admission to the intensive care unit. We have identified the blood level of soluble urokinase plasminogen activator receptor (suPAR) as a promising blood test to differentiate between patients at high or low risk of progressing to respiratory failure. Our research focuses on evaluating the ability of suPAR and other inflammatory biomarkers in triaging patients presenting to the emergency department with respiratory symptoms. April 15

  24. Assessing COVID-19 Using Social Media

    • Co-Principal Investigators: Al Hero, College of Engineering/College of Lit, Science & Arts & Co-PI is Walter Dempsey, School of Public Health

    • Project Summary: This project will build a database using social media Twitter) that will be used to study the spread of COVID-19 and its effects on the public, over time, and across the nation. April 15

  25. STOP-COVID: Study of the Treatment and Outcomes in critically ill Patients with COVID-19

    • Principal Investigator: Salim Hayek, MD, Medical School

    • Project Summary:  STOP-COVID is a multicenter observational/registry study of the clinical features and outcomes of critically ill patients with COVID-19. The goals of this project are to determine the independent risk factors for hospital mortality and acute organ injury, and to identify treatment strategies associated with improved survival. Additionally, we will assess outcomes according to differences in geographic and institutional parameters. April 15

  26. Monitoring of Clinical Care and Outcomes Related to Respiratory and Acute Illnesses

    • Principal Investigator: Joyce Lee, Medical School/School of Public Health

    • Project Summary: This project seeks to track clinical care and outcomes related to respiratory and acute illnesses of children and young adults at Michigan Medicine Department of Pediatrics for the purposes of clinical care operations, patient safety, and quality improvement. This project will collect data from the Michigan Medicine electronic medical record (EMR) for secondary analyses to assess health outcomes and clinical trajectories related to respiratory and acute illnesses in children and young adults.  April 15

  27. Socially Distant - Understanding Post COVID College Education

    • Principal Investigator: Suzanne Perkins, College of Lit, Science and Arts

    • Project Summary: College students are surveyed on their experiences with post-covid educational practices and their abilities to attend, maintain motivation and use executive functioning skills during distance learning. We are particularly interested in differences in family background, current living environment, financial worries, social support and responsibilities such as care taking, work. April 17

  28. Evaluating Post-Intensive Care Syndrome (PICS) and Other Medical and Medication Related Needs in COVID19 Intensive-Care Unit (ICU) Survivors compared to non-COVID19 ICU Survivors

    • Principal Investigator: Rima Mohammad, College of Pharmacy 

    • Project Summary: The purpose of this study is to assess potential medical, medication and PICS related needs for COVID19 ICU survivors post-hospital discharge. The proposed project would lay the foundation for future work exploring the role of innovative, interprofessional practice model to care for and to support a high-risk population of COVID19 ICU survivors. April 22 

  29. SURVEY08 COVID-19 Response: Face Shield Manufacturing at U-M

    • Principal Investigator: Alexandra Vinson, Medical School

    • Project Summary: As part of the COVID-19 response at the University of Michigan, several sites on campus began designing, prototyping and manufacturing face shield components. We are conducting a case study examining cross-site coordination in face shield production in order to understand how existing infrastructure and knowledge can be repurposed in a rapid response situation.  April 22

  30. SURVEY01 The Impact of the Coronavirus (COVID-19) Pandemic on Adults with Low Vision in Southeast Michigan

    • Principal Investigator: Joshua Ehrlich, Medical School 

    • Project Summary: The current novel coronavirus (COVID-19) pandemic has the potential to substantially and broadly impact functioning and vision-related quality of life (VR-QOL) for individuals with low vision. This study will survey adults with and without low vision at multiple institutions in southeast Michigan in order to measure the impact of the pandemic on functioning and VR-QOL. April 22

  31. History of Childhood Adversity in College Students during COVID19

    • Principal Investigator: Suzanne Perkins, College of LSA

    • Project Summary: We are studying the role of the history of childhood adversity on post COVID19 functioning in college students in the domains of sleep, wellness, and examining current social support, safety in their communities including exposure to violence and current living environment, responsibilities such as caretaking, work and financial worries. April 22

  32. SCCM Discovery VIRUS 

    • Principal Investigator: Pauline Park, Medical School

    • Project Summary: This SCCM Discovery multicenter study will prospectively evaluate a standardized data dictionary to facilitate real-time data reporting for critically ill COVID-19 patients. The study will report variations in COVID-19 ICU care across hospitals and will examine the effect on acute outcomes. April 22 

  33. How are Public Perceptions of Covid-19 Risks Related to Scientific Reasoning Ability?

    • Principal Investigator: Caitlin Drummond, School for Environment and Sustainability

    • Project Summary: We examine how the ability to evaluate scientific evidence critically, known as scientific reasoning ability, is related to perceptions of individual and societal risk stemming from the novel coronavirus, and engagement in risk mitigation behaviors. April 27 

  34. Qualtrics COVID survey to 45,000 CBR-consented MM patients

    • Principal Investigator: Cristen Willer, PhD, Medical School

    • Project Summary:  The objective of the survey is to collect information from CBR study participants on COVID-19 symptoms, diagnoses, and exposure as well as limited health-related lifestyle, behavioral, and risk factor topics. April 27

  35. Public Health Messaging on Tik Tok During the COVID-19 Global Pandemic

    • Principal Investigator: Ellen Selkie, Medical School 

    • Project Summary: This project examines influencer-created content on the social media platform TikTok during the current global pandemic to describe the messaging received by many young people using the platform. Content related to COVID19 will be reviewed for adherence to CDC guidelines about infection prevention and for presence of disinformation regarding the virus. April 27

  36. Covid-19 pandemic and centralized pain in surgical patients

    • Principal Investigator: Joel Gagnier,  Medical School / School of Public

    • Project Summary: HealthThe COVID-19 pandemic has had a profound impact socially, physically and psychologically for most people. This study examines the impact these stressors place on surgical patients. We will compare pain and other outcomes in patients before the COVID-19 pandemic to during the pandemic. May 5

  37. Development of COVID-19 specific patient reported outcome measure (PROM)

    • Principal Investigator: Joel Gagnier, Medical School / School of Public Health

    • Project Summary: This study will survey health professionals and COVID+ patients using scale construction methods to develop a COVID-19 specific patient reported outcome measure for use in clinical research and monitoring. We will use PROMIS items and test the resultant measure using various methods to establish norms and scale properties. We will then disseminate and translate the scale to enable wide use. May 5

  38. HEART: COVID Recovery Stories

    • Principal Investigator: Theodore J. Iwashyna, Medical School

    • Project Summary: Documenting the needs of COVID patients and their informal caregivers through story-telling and qualitative interviews. This project supports the future development of COVID caregiver/patient resources and interventions to support recovery from home. May 5

  39. Supplement to Alzheimer’s Disease Risk and Ethnic Factors: The Case of Arab Americans (R01AG057510)

    • Principal Investigator: Kristine Ajrouch, Institute for Social Research

    • Project Summary: This application for an NIA Administrative Supplement proposes to expand Alzheimer’s Disease Risk and Ethnic Factors: The Case of Arab Americans (R01AG057510) to incorporate COVID-19 stress as an area of investigation. May 5

  40. The influence of socio-cultural ecologies on the COVID-19 pandemic

    • Principal Investigator: Shinobu Kitayama, College of Lit, Science & Arts Institute for Social Research

    • Project Summary: We examined whether global variation in COVID-19 confirmed cases would be predicted by relational mobility, the community-level tendency to engage with strangers, and freely choose friends. We found relational mobility predicted an increased growth rate of cases across 37 countries, after controlling for relevant demographic and cultural variables. May 5

  41. Examining post-acute care challenges and considerations amidst Covid-19

    • Co-Principal Investigators: Jun Li and Minakshi Raj,  School of Public Health Health Management & Policy  

    • Project Summary: This study examines how hospitals are discharging patients to post-acute care during the COVID-19 pandemic including challenges, concerns, and opportunities for improvement. May 5

  42. Access to Health Services among Uninsured Population Enrolled in Genesee Health Plan: A Community Health Needs Assessment: Wave 2

    • Principal Investigator: Reza Amini, College of Health Sciences UM Flint

    • Project Summary: Genesee Health Plan (GHP) is a program aims to eliminate access to health services among uninsured and under insured population. We collected data last year about health needs and effectiveness of GHP. In the second wave, we will contact the same participants and ask about the impact of COVID-19 on their health status and needs, also, about the role of GHP. May 5

  43. ​Home remedies when recovering at home with COVID-19-suspect symptoms.

    • Principal Investigator: Margit Burmeister, Medical/Computational Medicine & Bioinformatics

    • Project Summary: We will ask participants about what home treatments they are trying/ tried when recuperating at home with COVID-19 suspected symptoms. May 5

  44. Comparison of the lived experiences of the Korean and the U.S. nurses working through the COVID19 pandemic

    • Principal Investigator: Jin Jun, School of Nursing 

    • Project Summary: This study explores the lived experiences of nurses at work and in life during the COVID-19 pandemic. The findings from this study will provide a deeper understanding of the nurses’ experiences, their needs, coping skills, and the reasons for continuing their work in the context of different cultures. May 11

  45. Evaluation of ocular manifestations of COVID-19 patients

    • Principal Investigator: Shahzad Mian, Medical School

    • Project Summary: We aim to investigate the ocular manifestations of COVID-19 patients at Michigan Medicine. We will conduct a retrospective chart review of COVID-19 patients to assess for the presence of ocular symptoms and follow up with a phone survey to evaluate if patients experience ocular manifestations during the recovery phase. May 11 

  46. Understanding family caregivers' concerns and experiences related to Covid-19

    • Principal Investigator: Minakshi Raj, Medical School / School of Puiblic Health

    • Project Summary: This study seeks to understand experiences and concerns of family caregivers of adults age 60 and older, during the Covid-19 pandemic. May 11

  47. 2020 Speak to Your Health! Community Survey

    • Principal Investigator: Daniel J. Kruger, Institute for Social Research

    • Project Summary: The Speak to Your Health! Community Survey is a Community-Based Participatory Research (CBPR) project that examines a wide range of issues related to individual and community health in Genesee County, Michigan. The survey has been conducted every other year since 2003, the 2020 survey wave incorporates questions related to COVID and its impact on community health. May 11

  48. The BRAINS Study - Brain Relationships Among Information, Neuroprocessing, and Self-Management

    • Principal Investigator: Lenette M. Jones, School of Nursing

    • Project Summary: We are exploring relationships among blood pressure control, diabetes status, cognition, and self-management among African American women with hypertension; and how changes related to COVID-19 may impact self-management behavior.  May 13

  49. Flashbulb memories of COVID-19

    • Principal Investigator: Arlo Clark-Foos, Dearborn Col of Arts, Sci & Letters 

    • Project Summary: The project I am starting is examining the vivid, emotional, flashbulb memories for the University and State shutdowns and stay at home orders. May 13

  50. COVID19 messaging in social media: effect of source and content

    • Principal Investigator: Rachel Solnick, IHPI

    • Project Summary: Evaluating the message content and messenger of simulated Twitter profiles on participant's perceived message effectiveness, willingness to share the post, and writing a letter to their governor to support continuing public activity restrictions. May 13

  51. RAPID: Children's Biological Beliefs Concerning COVID-19 Disease Transmission

    • Principal Investigator: Susan Gelman, LSA

    • Project Summary: This NSF-funded project will map out what children 5-12 years of age understand about the transmission of COVID-19, by conducting a comprehensive, cross-age assessment with U.S. families in the midst of this global pandemic. The research will assess what children know, what they don't know, and what they think they know (but is scientifically inaccurate). May 13

  52. Digital Assistance to Help People Cope with the COVID-19 Outbreak

    • Principal Investigator: Rada Mihalcea, College of Engineering

    • Project Summary: We are developing an AI-assisted online interface where people can write about the major issues they are facing during the COVID-19 outbreak. The system will use natural language processing to analyze the responses and provide personalized feedback and pointers to useful resources. May 13

  53. 4CE i2b2 using ACT infrastructure

    • Co-Principal Investigators: Gilbert Omenn -Medical School/School of Public Health, David Hanauer - Medical School/School of Information

    • Project Summary: The Consortium for Clinical Characterization of COVID-19 by EHR (4CE) is an international consortium for electronic health record (EHR) data-driven studies of the COVID-19 pandemic. The i2b2 tranSMART Foundation is mobilizing multiple i2b2 sites in the US, Singapore, and Europe to test whether basic data can be generated from EMR systems to show trajectories of the COVID-19 pandemic. The goal is to inform doctors, epidemiologists, and the public about COVID-19 patients with data acquired through the healthcare process. In only a few weeks, the Michigan Institute for Clinical & Health Research (MICHR) implemented an i2b2 ontology for COVID-related concepts and customized mappings for the new COVID concepts, transformed the data from our EHR, and submitted it to the tranSMART file share. This will be an iterative and ongoing process. This data can be updated on a weekly basis (or more if needed) to respond quickly to future requests for data. May 13

  54. Maternal ethylenethiourea levels, newborn thyroid function & infant development - Handal Cohort Study

    • Principal Investigator: Alexis Handal, School of Public Health

    • Project Summary: The SEMILLA (Study of Environmental Exposure of Mothers and Infants Impacted by Large-Scale Agriculture) cohort study follows pregnant women and their infants up to 18 months of age in an agricultural region of Ecuador to assess how toxic exposure, combined with key social and structural factors, impact child growth and development. SEMILLA incorporates prenatal measures of pesticide exposure and key social and structural factors including working conditions, environmental exposures in home and work environments, stress, social support, maternal health and lifestyle, socio-economic and demographic factors. Participants already enrolled in SEMILLA will participate in a qualitative phone interview to assess the impact of the COVID-19 pandemic on their pregnancy, their home life and responsibilities, their social support system, and their economic situation. May 29

  55. The COVID-19 Self-Management Study: Living With Chronic Conditions During the COVID-19 Pandemic

    • Principal Investigator: Courtney A. Polenick, PhD, Medical School

    • Project Summary: We are conducting an online survey study to understand the experiences of adults aged 50 and older in the United States who are living with at least one chronic condition (mental or physical) during the COVID-19 pandemic. May 29

  56. COVID-19 Rapid Response Research Registry

    • Co-Principal Investigators: Emily Somers, Medical School & School of Public Health & Emily Martin, Public Health

    • Project Summary: To aid accessibility to crucial COVID-19 patient data, the COVID-19 Rapid Response Research Registry offers a centralized clinical characterization and management resource of what the scientific and health care community has learned through this public health pandemic. Rather than working in isolation and duplicating effort, scientists are connecting across the globe, sharing lessons learned from treating patients and research breakthroughs to save lives. The Registry will gather data from coronavirus patients to inform front-line clinical care decisions in real-time, trends in treatments, hospital-level projections, and future research designs. The registry was created by the Michigan Institute for Clinical & Health Research (MICHR) and partners from the School of Public Health, Institute for Healthcare Policy and Innovation, the Medical School, and more. The COVID-19 Rapid Response Research Registry will be a part of the international consortium ISARIC, thus contributing to patient data collected around the globe. June 2

  57. Thin CDM for PaTH/ PCORNet

    • Co-Principal Investigators: Dave Williams - Medical School/MICHR, David Hanauer - Medical School/School of Information/MICHR

    • Project Summary: MICHRs Network-based Research Unit and Informatics teams are collaborating with the U-M Health Information Technology & Services (HITS) and the Data Office for Clinical and Translational Research (DOCTR) to meet an urgent need of the National Patient-Centered Clinical Research Network (PCORnet) to establish a COVID-19 surveillance and tracking plan. The US Center for Disease Control & Prevention (CDC) regularly engages in public health surveillance so that systematic collection and analysis of health-related data can drive its public health practice. In mid-March, the CDC approached PCORnet seeking data on COVID-19-positive patients. In less than three weeks, the MICHR team compiled a “thin” version of the Common Data Model (CDM) specifically for the rapid study of COVID-19 that only includes patients testing positive for the virus or with a coronavirus-related ICD-10 code. In addition, the project produced a query that can be reissued weekly (unlike the full CDM), so sites will have an opportunity to join effort once they are ready.  June 2

Medical Device Development

  1. Rapid Cytokine Measurement in Patients with COVID19

    • Principal Investigator:Benjamin Singer, School of Engineering

    • Prpject Summary: This project is examining the use of a rapid microfluidic cytokine assay developed in the College of Engineering to determine feasibility and acceptability of returning cytokine levels to treating clinicians in patients with COVID-19. Primary Objective: To provide clinicians with rapid information regarding cytokine levels in critically ill patients with COVID19. Secondary Objectives: To determine if rapid determination of cytokine levels contributes to medical decision making in critically ill patients with COVID19; To determine if cytokine levels correlate to other clinically used nonspecific markers of inflammation and organ injury. School of Engineering March 31

  2. Open Source Rapidly Produced Improvised Ventilator

    • ​​Principal Investigator: Max Witt, Medical School

    • Project Summary: We are a team of medical students and engineers that are working to develop a rapidly producible system to allow a single, non-invasive ventilator to support multiple patients with individual settings and without cross-contamination, or potentially serve as an improvised standalone ventilator. Our design avoids the use of uncommon or potentially difficult to obtain parts, and we plan to open-source the final version. March 31

  3. Variation in Aerosol Production in Spontaneously Breathing Human Subjects

    • ​​Principal Investigator: Theodore Iwashyna, Medical School

    • Project Summary: The goal of this project was to collaborate between ICU clinicians and mechanical engineers to bring human data to bear on a critical question: how safe are alternative modes of oxygen support, from an infection control perspective? What might spread potential infections less? March 31

  4. ​Disposable face shields as PPE for healthcare workers

    • Principal Investigator: Max Shtein, College of Engineering/Stamps School of Art & Design

    • Project Summary: A team of U-M researchers is looking to develop rapidly manufacturable, disposable face shields for healthcare workers who interact with COVID-19 patients. Researchers are using a combination of 3D printing, laser cutting and folding, leveraging experience they acquired through several ongoing, NSF-sponsored projects, including kirigami materials and devices, pharmaceutical printing and additive manufacturing. April 2

  5. ​Coronavirus inactivation with UV and solar radiation, transfer with surfaces, and wastewater monitoring

    • ​​Principal Investigator: Krista Wigginton, College of Engineering

    • Project Summary: Our NSF RAPID project seeks to characterize the rate of the transfer of enveloped viruses between hands and surfaces, to measure inactivation kinetics of coronaviruses with UV radiation and sunlight, and to capture the dynamics of SARS-CoV-2 circulating in a community by monitoring wastewater. April 3

  6. ​Assessing PPE recycling approaches

    • ​​Principal Investigator: Krista Wigginton, College of Engineering

    • Project Summary: An internal project helping Michigan Medicine implement a recycling program for N95 masks. This collaborative project between researchers in COE and Michigan Medicine involves studying how effective different treatments are at inactivating viruses deposited on N95 masks. April 3

  7. Plasma treatment to destroy corona virus (masks and surfaces)

    • ​​Principal Investigator: John Foster, College of Engineering

    • Project Summary: A team of U-M researchers is developing plasma-based systems in an effort to contain the spread of COVID-19. Their plasma-based treatment aims to eliminate the virus on surgical and N95 masks, along with aerosols and surfaces, so that clinical personnel can operate safely without the risk of airborne infection. April 3

  8. Respirator Mask/Mask Materials Efficacy Testing

    • ​​Principal Investigator: Herek Clack, College of Engineering

    • Project Summary: Experimental measurement of particles as small as 11 nm and their penetration through various respirator (N95) masks and other materials submitted for use in DIY fabricated surgical masks. Includes testing of the loss of filtration efficacy of masks and mask materials after different standard and novel sterilization treatments for the purposes of mask recycling/reuse. April 6

  9. COVID-19 Mechanical Ventilation Splitter Device Yalamanchi, Pratyusha

    • ​​Principal Investigator: Glenn Green, Medical School

    • Project Summary: A ready device to solve the ventilator shortage. We are testing a device that allows individualized pressure control for patients needing ventilatory support when ventilators are unavailable. April 6

  10. ​Testing Novel Mechanical Ventilators in Pre-clinical Animal Models

    • ​​Principal Investigator: Alvaro Rojas, Medical School

    • Project Summary: The University of Michigan Extracorporeal Life Support Laboratory, is collaborating with clinicians, scientists, and industry in preclinical testing of new mechanical ventilators and respiratory devices developed to treat patients in critical condition due to COVID-19 infection. Our mission is to solve current clinical problems and perform animal studies to collect physiological (normal and disease simulation) data for FDA applications prior to clinical use. April 13

  11. ​Wearable Negative Pressure Ventilation System

    • Co-Principal Investigators: Swo-For Ward, Bassin, Kota, Haas & Hornick; Medical School

    • Project Summary: Wearable device enables the isolated use of a Heated High Flow Nasal Cannula (HFNC) or nebulized medications, sparing the need for a mechanical ventilator or potentially allowing earlier transition from mechanical ventilation. The device’s compact design effectively creates a personal negative pressure environment wherever the patient is, and it maintains that environment even if the patient requires movement (imaging, testing, bathroom, etc.). keward@umich.edu, kota@umich.edu, bsbassin@med.umich.edu, haasn@med.umich.edu April 14

  12. Cold Adaptive Atmospheric Plasma Dry Decontamination of COVID-19

    • Principal Investigator: John Foster, College of Engineering

    • Project Summary: The objective of this work is to develop a portable and scalable plasma source for the disinfection and sterilization of surfaces. The applicator generates reactive oxygen species along with UV and ultrasound that both mechanically disrupts and chemically erodes away biological contagions as well chemical contaminants of concern. April 28

  13. Plasmonic Optoelectronic Immunosensor for Point-of-Care Virus Infection Screening

    • Principal Investigator: Katsuo Kurabayashi, College of Engineering

    • Project Summary: This project aims to develop a novel smartphone-connected, battery-operated miniature portable biosensor platform for SARS-CoV-2 detection for its translation to point-of-care (POC) and home-based testing. Using the aimed device, we will explore a new rapid and sensitive on-chip diagnostic approach to directly detect the presence of SARS-CoV-2 virus particles in a nasal swab, saliva, or urine without PCR amplification and without any steps of sample processing, modification, labeling, or washing. The detection strategically employs label-free plasmonic biosensing with gold nanoparticles (AuNPs) specifically targeting the spike protein of SARS-CoV-2 and near-infrared (NIR) optical transmission signal detection with an ultralow-noise 2D-layered transition metal dichalcogenide (TMDC) photoconductive channel.  May 13

  14. Michigan Medicine-Telemedicine Care Program

    • Principal Investigator: Melvyn Rubenfire, Medical School

    • Project Summar: New fully home based clinical care paradigm for chronic care management of cardiovascular disease can be used for COVID-19 patients and those at high risk using telemedicine with novel personal devices for blood pressure, weight, blood sugar, oxygen saturation, activity, sleep and medication compliance that provide patient data to the EMR several times daily and are reviewed by the care team regularly and with alarms. Care team coordinates with physicians and provides ongoing education regarding diet, activity, and medical treatments and makes adjustment of medication as needed for targets with evidence based guidelines. May 13 

Public Policy Analysis and Impact

  1. Support for Executive Decree Authority and the Severity of Crisis 

    • Principal Investigator: Kenneth Lowande, College of Literature, Science, and the Arts

    • Project Summary: This project fields a nationally-representative survey to determine whether support for the enactment of various COVID-19 public policy responses via executive order is conditional on the localized severity of the pandemic. March 31

  2. ​The Effect of COVID-19 on Food Insecurity in the United States

    • Principal Investigator: Julia Wolfson, School of Public Health

    • Project Summary: The coronavirus pandemic and the societal changes it has prompted are profoundly and quickly changing American life. Americans are being asked to work from home, non-essential businesses are closing, and schools and daycares are closed. These changes have the potential to exacerbate food insecurity among low-income Americans. For this survey research study, we fielded a national online survey of low-income adults in the U.S. to measure the effect of the COVID-19 outbreak on food insecurity and other health outcomes. We will field the survey on March 19-24, just as distancing measures are just starting to be implemented. A similar follow up survey will be conducted in approximately three months. April 2

  3. ​Michigan Public Policy Survey of Local Government Leaders on COVID-19

    • ​​Principal Investigator: Thomas Ivacko, Ford School of Public Policy

    • Project Summary: We are surveying Michigan's local government leaders to learn about the expected impacts of the COVID-19 pandemic in their communities, how effectively various governments are coordinating efforts, what kinds of resources they need, how long they expect various impacts to last, and more. April 2

  4. Pandemic Divergence: Understanding the Comparative Politics of Emergency Diagnostic Testing

    • ​​Principal Investigator: Shobita Parthasarathy, Ford School of Public Policy/College of Literature, Science, and the Arts

    • Project Summary: This project compares the development, implementation, and governance of covid19 diagnostic testing, comparing the US, UK, Singapore, and South Korea. Its aim is to understand how political culture has shaped government, private sector, and societal responses, with the aim of developing better, more equitable and effective policies for the current and future pandemics. April 3

  5. DMACS - COVID Rapid Response Supplemental Survey

    • ​​Principal Investigator: Elisabeth Gerber, Ford School of Public Policy

    • Project Summary: DMACS is an ongoing representative panel survey of Detroit adults. DMACS is fielding multiple short survey waves to better understand how Detroiters are experiencing the health, social and economic consequences of the pandemic; what preventative behaviors are they taking; how are they grappling with new financial hardships; and how much do they support various public policy approaches to dealing with the crisis. April 6

  6. Exploring Parents' Experiences of Service Access and Parenting Stress During the COVID-19 Pandemic

    • ​Principal Investigator: Anne Blumenthal, College of Literature, Science, and the Arts/Institute for Social Research

    • Project Summary: Through longitudinal surveys, this study asks: How are parents faring during this crisis? How are their parenting challenges related to their economic resources? How are parents getting the help they need and who are they receiving it from? April 6

  7. Community Assessment for Pubic Health Emergency Response

    • ​​Principal Investigator: Judith Policicchio, School of Nursing

    • Project Summary: Senior-level nursing students, along with their Clinical Instructor, Judi Policicchio, are working together to assess the impact of the Covid-19 Epidemic using the CDC’s Community Assessment for Public Health Emergency Response toolkit. Questions from the toolkit were selected for the Covid situation. April 9

  8. ​May Hospitals Withhold Ventilators from COVID-19 Patients with Pre-Existing Disabilities? Notes on the Law and Ethics of Disability-Based Medical Rationing, 130 YALE L.J.F. ___ (forthcoming 2020)

    • Principal Investigator: Samuel Bagenstos, Law School

    • Project Summary: This article, forthcoming in the Yale Law Journal Forum, addresses the question whether health may legally base rationing decisions for life-saving treatments on a patient's pre-existing disabilities. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3559926 April 13

  9. ​Documenting and Analyzing Anti-Asian, Coronavirus-Related Hate Incidents in the U.S.

    • Principal Investigator: Melissa Borja, College of Lit, Science & Arts

    • Project Summary: This national research project, done in collaboration with scholars and community partners across the country, collects and analyzes data about anti-Asian, coronavirus-related hate incidents in the United States. Researchers are analyzing trends in anti-Asian hate as documented through a national hate incident reporting system, as well as through news coverage and social media. April 14

  10. Why Should I Wear Face Masks? Self-Protection and Personal Social Responsibility

    • Principal Investigator: Jun He, Dearborn College of Business

    • Project Summary: The research studies people’s reactions to wearing face masks in public amid the Covid-19 pandemic. The purposes are to enrich our understanding of how people view precautionary measures, and to make implications for public health policies and government actions to cope with the pandemic. April 15 

  11. Local Government COVID-19 Fiscal Strategy and Resource Guide

    • Principal Investigator: Stephanie Leiser, Ford School

    • Project Summary: We are organizing a group of public finance experts from universities, consulting firms, and research institutions from around the state to create a website to provide strategic fiscal advice and information for local governments in response to COVID-19. The website will include a series of briefs on various aspects of local finances (emergency spending, revenue shortfalls, budget cuts, etc.) as well as up to date information on federal/state programs designed to assist local governments. April 22

  12. Is Heading Home a Dead End? COVID-induced Migration and Local Labor Market Opportunities in Rural India

    • Principal Investigator: Yusef Neggers,  Ford School of Public Policy

    • Project Summary: We are conducting phone surveys with return migrants in the large Indian state of Bihar. Our primary aims are to: better understand the labor market and broader economic impacts of COVID-19 and the resulting lockdown; and convey timely insights from these data to state leadership, in order to inform policy priorities related to COVID-19, rural labor markets, and internal migrants. April 28 

  13. Postsecondary Decision Making

    • Principal Investigator: Elizabeth Burland, Rackham - student

    • Project Summary: My study investigates how students make decisions about what to pursue after high school; how school, family, and geographic contexts shape these decisions; and how financial aid interventions influence student decision making. Amid the COVID-19 pandemic, how have students changed their decision-making around what to do after high school, and how has the pandemic affected access to networks and resources used to make decisions. May 5

  14. Measuring eligibility for the Paycheck Protection Program with respect to restrictions on criminal histories of equity owners

    • Principal Investigator: Michael Mueller-Smith, Institute for Social Research / College of Lit, Science & Arts

    • Project Summary: This research seeks to quantify the impact of restrictions for current or past involvement with the criminal justice system on eligibility for the U.S. Small Business Administration’s Paycheck Protection Program (PPP). To estimate the proportion of small business owners who have been excluded from the PPP, we will use the University of Michigan's Criminal Justice Administrative Records System (CJARS) data platform linked with IRS 1040 individual tax form data (Schedule C and Schedule SE filing flags) and U.S. Census Bureau demographic data to identify the size of and describe the impacted population. May 13 

  15. SMDM COVID Decision Modeling Initiative (CDMI)

    • Principal Investigator: Lisa Prosser, Medical School

    • The SMDM COVID Decision Modeling Initiative (CDMI) seeks to develop and advance new ideas and scalable approaches to address uncertainties during the COVID-19 pandemic by catalyzing innovation in decision models for rapid uptake and impact. To kick off this effort, we are requesting proposals for projects developing, tailoring, and communicating decision models for COVID-19 response to policy, health system, or clinical choices. May 29

  16. ​Study of Pandemic Publishing: How Scholarly Literature is Affected by COVID-19 Pandemic

    • Principal Investigator: Yulia Sevryugina, Library

    • Project Summary: Our hypothesis is that COVID-19 related changes in publication policies inadvertently promote poor scholarship; as such, we will analyze COVID-19 published literature for incoherent writing, stylistic errors, plagiarism, speculative language, reproducibility, and far-fetched conclusions based on poor quality data. We also plan to examine and monitor retracted and corrected manuscripts, explore their citation maps to determine how errors propagate through scholarly literature, as well as scrutinize reasons for retractions. May 29

Stress and Mental Health During COVID-19

  1. Parenting Stress During a Global Health Crisis

    • ​​Principal Investigator: Shawna J. Lee, School of Social Work

    • Project Summary: The survey examined parenting, mental health and coping skills, and romantic relationships during the Coronavirus pandemic. March 31

  2. ​Impact of COVID-19 on Women's Pregnancy-Related Anxiety

    • Principal Investigator:  Cheryl Moyer, Medical School

    • Project Summary: Online survey of pregnant women to determine how the COVID-19 pandemic has affected their antenatal care, their delivery plans and their anxiety level. March 31

  3. Social Wellbeing during COVID-19

    • ​​Principal Investigator: Ivy F. Tso, LSA/Medical School

    • Project Summary: My study is an anonymous, online survey aiming to understand people's health and mental health during the pandemic of COVID-19 in different countries. March 31

  4. Emotion Regulation in Daily Life during COVID-19 Pandemic

    • Principal Investigator: Sujin Lee, College of Literature, Science, and the Arts

    • Project Summary: Our project aims to understand individuals' levels of stress and anxiety on the COVID-19 pandemic and how individuals regulate their distress using EMA (Ecological Momentary Approach). We hope to identify adaptive regulatory strategies to promote better psychological wellbeing in this anxiety-provoking epidemic crisis. March 31

  5. ​​The COVID-19 Coping Study: A Longitudinal, Online Survey of Older Americans' Health and Well-being during the COVID-19 Pandemic

    • ​​Principal Investigator: Lindsay Kobayashi, School of Public Health; Jessica Findlay, Institute for Social Research

    • Project Summary: The aim of the COVID-19 Coping Study is to understand how the COVID-19 pandemic and associated control practices and policies are affecting the mental health and well-being of older adults in America, and to identify strategies that help older adults to cope. The goal is to generate knowledge that can be used to inform best practices to support health and well-being of older adults during public health crises. The researchers are using a multi-frame sampling strategy, first through an online panel with quotas for age, sex, and race/ethnicity to match the general older population, and then through distribution through professional society networks, professional contacts, mailing lists of seniors' organizations, and social media. April 3

  6. ​​Michigan Twin Neurogenetics Study

    • ​​Principal Investigator: Luke Hyde, College of Literature, Science, and the Arts/Institute for Social Research

    • Project Summary: The overall study aim is to examine how poverty-related adversity undermines brain development to increase risk for these maladaptive outcomes. The addition of a COVID-19 stress assessment will permit us to examine the impact of this exogenous stressor on youth and families in real-time so we can better understand the economic, social and psychiatric impact of COVID-19 on low-income families and the impact on adolescent brain and behavior development, overall. April 6

  7. Parent Well-being and Resilience: Coping with COVID-19

    • Principal Investigator: Sharon Lo, School of Public Health

    • Project Summary: Investigating the well-being of parents their family during the COVID-19 outbreak. April 2

  8. ​Staying Sane in the Midst of an Epidemic

    • Principal Investigator: Mustafa Naseem, School of Information

    • Project Summary: Limited mobility will more adversely affect populations with precarious life situations such as low-income groups with limited savings, precariously-employed populations, including workers who work for tips, taxi drivers (Uber/Lyft) who make their income per-ride, etc. Our research goals are to understand (a) the anxieties that these populations are facing due to the changing pandemic situation and associated curtailing measures, (b) how do these populations maintain and foster their and their families' mental health, (c) could there be a role that technology can play in providing material or emotional support to these communities? April 2

  9. ​​Concurrent Stress in Couples During COVID-19

    • ​​Principal Investigator: Amie M. Gordon, College of Lit, Science & Arts

    • Project Summary: Four-wave longitudinal study assessing changes in the quality of romantic relationships among cohabiting couples who are sheltering-in-place in response to the COVID-19 pandemic. Surveys will be completed at baseline (T1), +2-3 weeks (T2), +3 months (T3), and +6 months (T4) and will focus on people's experiences with the covid pandemic and current situation, as well as their current psychological state (particularly levels of stress), their relationship quality and relationship-relevant behaviors, perceptions of how their relationship has changed since the pandemic began, expectations for how their relationship will be in the future, and objective relationship outcomes at T4. April 7

  10. AIMS-T1D Follow Up Coping Study

    • Principal Investigator: Alison Miller, School of Public Health

    • Project Summary: Purpose of study is to compare parent and child emotional coping strategies, family conflict and diabetes management, and teen medical regimen adherence before and after COVID19 to determine potential impact of a community trauma like COVID19 on these outcomes. We will assess these constructs by conducting follow up interviews with an existing sample of families of adolescents who have Type 1 Diabetes who have completed these measures previously. April 7

  11. ​​Parent Risk, Resilience, and Well-Being: Coping with COVID-19

    • ​​Principal Investigator: Sharon Lo, School of Public Health

    • Project Summary: The aim of this study is to understand how parents and their families are adapting and responding to the stress related to the COVID-19 outbreak. Previous research suggests that global crises pose severe risks for people's mental and physical health. However, our understanding of factors that may actually bolster and support well-being and resilience of parents and their families during the COVID-19 outbreak is unknown. We use a longitudinal design to identify factors that predict parents' well-being in order to inform best practices that support positive functioning during public health crises. April 7

  12. ​Experiences and Well-being of College Students during the Pandemic

    • Principal Investigator: Daniel Eisenberg, School of Public Health

    • Project Summary: By adding new questions to our national survey study of college student mental health, the Healthy Minds Study, we will examine the experiences and well-being of students during the pandemic. April 13

  13. Managing Severe Eating Disorders in the Context of COVID-19: Transition of a Partial Hospitalization Program to Virtual Care

    • Principal Investigator: Jessica Van Huysse, PhD, Medical School

    • Project Summary: This project will examine the effectiveness of the virtual care treatment program that the Michigan Medicine Comprehensive Eating Disorders Program rapidly adopted in response to COVID-19. The virtual care program replaced the usual in-person partial hospitalization program. Patient satisfaction and perceptions of the impact of COVID-19 on eating disorder symptoms and treatment will be assessed via survey, and treatment progress will be examined using both within- and between-person analyses.  April 15

  14. History of Childhood Adversity in College Students During COVID19

    • Principal Investigator: Suzanne Perkin, College of Lit, Science and Arts

    • Project Summary: We are studying the role of the history of childhood adversity on post COVID19 functioning in college students in the domains of sleep, wellness, and examining current social support, safety in their communities including exposure to violence and current living environment, responsibilities such as caretaking, work and financial worries. April 17 

  15. SURVEY12 Psychological Stress in Pediatric and Adult Congenital Heart Disease Patients and Caregivers During the COVID-19 Pandemic

    • Principal Investigator: Melissa Cousino, Medical School

    • This survey study will seek to describe psychological stress in pediatric and adult patients with congenital heart disease and their caregivers as it relates to COVID19 and the impact of the pandemic on their healthcare. Results will inform care delivery and support needs during and post-pandemic. April 22

  16. Relationships between anxious feelings and behavioral traits

    • Principal Investigator: Sonalee Joshi, College of Lit, Science &Arts

    • Project Summary: This study will examine the relationship between self-reported anxiety-based avoidance and dimensional impulsivity across several time periods with respect to the COVID-19 stay-at-home order in the United States. We aim to assess potential changes in anxiety and impulsivity over this period of time. April 27

  17. Parent and Child Wellbeing during the COVID-19 Pandemic

    • Principal Investigator: Andrea Roberts, College of Lit, Science & Arts

    • Project Summary: My study investigates whether children's coping skills and relationships with their parents may buffer against the negative effects of the COVID-19 pandemic on childhood wellbeing. I am also interested in understanding how parental stress, anxiety, and depression may impact childhood well-being during this crisis. April 27

  18. Stressful Life Events and Anxious Symptoms among Essential Workers during COVID-19: Locus of Control as a Moderator

    • Principal Investigator: Abigael Lucas. College of Lit, Science & Arts

    • Project Summary: The aim of this study is to understand the relations between stressful life experiences and symptoms of anxiety among essential workers during the COVID-19 pandemic, and examine locus of control as a possible moderator. April 27

  19. Longitudinal Study of Bipolar Disorder

    • Principal Investigator: Melvin McInnis, Medical School

    • Project Summary: Survey research on an existing longitudinal cohort of individuals with and without bipolar disorder to determine the impact of COVID-19 and related restrictions on health and functioning across time. April 28

  20. Michigan House Officer Well-Being During COVID-19

    • Principal Investigator: Heather Burrows, MD, PhD, Medical School

    • Project Summary: We are conducting a study to understand more about how training programs have provided support for house officer wellbeing during the response to the COVID19 pandemic. This will involve a survey of both PDs and House Officers at the University of Michigan. May 5

  21. Thriving Together: Promoting Early Positive Development

    • Principal Investigator: Katherine Rosenblum, Medical School

    • Project Summary: We are currently funded to rigorously evaluate of the effectiveness of the Infant Mental Health Home Visiting (IMH-HV) model on maternal and child outcomes according to legislative standards via a randomized controlled trial. In addition to originally proposed assessments, we will add COVID-19 specific assessments to: 1. Learn how participation in IMH-HV services could potentially buffer families’ response to stress associated with COVID-19; 2. Determine potential confounding effects of COVID-19 on ongoing data collected; 3. Provide valuable information on associations between families’ experience with the COVID-19 pandemic and other maternal and child data. May 13

  22. Natural Language Processing to Understand Changes in Mental Health

    • Principal Investigator: Rada Mihalcea, College of Engineering

    • Project Summary: We are developing natural language processing methods to understand the changes in mental health associated with the outbreak, as expressed on social media and online forums, and whether certain people are more susceptible to be affected by these changes. May 13​

  23. Romantic Relationships, Internet Use, and Adjustment

    • Principal Investigator: Brian Hicks, ​Medical School College of Lit, Science & Arts 

    • Project Summary: The general purpose of this research is to examine associations between romantic relationships, internet use, and adjustment. This particular survey is a follow up with a COVID-19 focus to measure the impact that the pandemic and the quarantine has had on mental health, substance use, and other areas. May 13

  24. Quality of Life in Older Adults with Hearing Loss Secondary to COVID-19 Precautions 

    • Principal Investigator: Rachel Fryatt, AuD, Univ Hospitals & Health Center

    • Project Summary: Identify the social impact of restrictions secondary to COVID19 pandemic, and identify differences in these perceptions in those who utilize hearing devices and those who do not. There is evidence to suggest that those with hearing loss are susceptible to social isolation, depression, and cognitive impairment, and the utilization of a hearing aid may reduce these effects; I am interested to see if the pandemic precautions affect those who wear hearing devices differently compared to older adults who do not. May 13 

  25. Media-Related Parenting During the Social-Distancing Period

    • Principal Investigator: Kristen Harrison,  College of Lit, Science & Arts Institute for Social Research   

    • Project Summary: Stay-at-home orders and closure of schools during the COVID-19 pandemic have put families in the position of managing their children's media use 24 hours a day. This survey of U.S. parents assesses parental mediation of child media use, parental stress, and parents' perceptions of children's media use as problematic. May 29

Questions?

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The Inter-university Consortium for Political and Social Research (ICPSR) has created a new archive for data examining the social, behavioral, public health and economic impact of the novel coronavirus global pandemic. The COVID-19 Data Repository is a free, self-publishing option for any researcher or journalist who wants to share data related to COVID-19. The data will be available to any interested user for secondary analysis. ICPSR has put together a resource page for guidelines on publishing data in the COVID-19 Data Repository and a Guide to Social Science Data Preparation that offers best practices to prepare data for sharing. Repository deposits are most useful if they include all data, annotated program code, command files, and documentation necessary to understand the data collection or replicate research findings.